期刊
VIRUSES-BASEL
卷 13, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v13101978
关键词
alphaviruses; flaviviruses; orthobunyviruses; Rhabdoviridae; Shuni virus; wildlife
类别
资金
- US CDC Global Disease Detection grant for Zoonotic arboviruses [5 NU2GGH001874-02-00]
- University of Pretoria
- UP Zoonotic Arbo and Respiratory virus program, 2012-2015
- NRF [95175]
- Meat Industry Trust [IT8114/98]
- Poliomyelitis Research foundation [15/112]
This study identified both veterinary and zoonotic arboviruses in pools of Culicoides biting midges in South Africa, indicating Culicoides as potential vectors for disease outbreaks in both animals and humans. The findings suggest that Culicoides may contribute to the spread of these viruses to new regions.
Culicoides-borne viruses such as bluetongue, African horse sickness, and Schmallenberg virus cause major economic burdens due to animal outbreaks in Africa and their emergence in Europe and Asia. However, little is known about the role of Culicoides as vectors for zoonotic arboviruses. In this study, we identify both veterinary and zoonotic arboviruses in pools of Culicoides biting midges in South Africa, during 2012-2017. Midges were collected at six surveillance sites in three provinces and screened for Alphavirs, Flavivirus, Orthobunyavirus, and Phlebovirus genera; equine encephalosis virus (EEV); and Rhaboviridae, by reverse transcription polymerase chain reaction. In total, 66/331 (minimum infection rate (MIR) = 0.4) pools tested positive for one or more arbovirus. Orthobunyaviruses, including Shuni virus (MIR = 0.1) and EEV (MIR = 0.2) were more readily detected, while only 2/66 (MIR = 0.1) Middelburg virus and 4/66 unknown Rhabdoviridae viruses (MIR = 0.0) were detected. This study suggests Culicoides as potential vectors of both veterinary and zoonotic arboviruses detected in disease outbreaks in Africa, which may contribute to the emergence of these viruses to new regions.
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