期刊
VIRUSES-BASEL
卷 14, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v14010156
关键词
tripartite motif protein 21 (TRIM21); porcine circovirus 2 (PCV2); immune response
类别
资金
- Jilin Province Science and Technology Development Projects [20200402043NC]
- Changchun Science and Technology Bureau project [21ZGN18]
- National Natural Science Foundation of China [31772747]
The study indicates that porcine TRIM21 plays a critical role in enhancing PCV2 infection by increasing interferons and proinflammatory factors while decreasing cellular apoptosis.
Tripartite motif protein 21 (TRIM21) is an interferon-inducible E3 ligase, containing one RING finger domain, one B-box motif, one coiled-coil domain at the N-terminal, as well as one PRY domain and one SPRY domain at the C-terminal. TRIM21 is expressed in many tissues and plays an important role in systemic autoimmunity. However, TRIM21 plays different roles in different virus infections. In this study, we evaluate the relationship between porcine TRIM21 and PCV2 infection as well as host immune responses. We found that PCV2 infection modulated the expression of porcine TRIM21. TRIM21 can enhance interferons and proinflammatory factors and decrease cellular apoptosis in PCV2-infected cells. These results indicate that porcine TRIM21 plays a critical role in enhancing PCV2 infection, which is a promising target for controlling and developing the treatment of PCV2 infection.
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