期刊
VIRUSES-BASEL
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/v14020432
关键词
virus; antiviral innate immunity; RNAi; small RNA; VSR
类别
资金
- NSFC [31870146]
- Fujian Province grant [2020J02014]
- Fujian Province Hundred-Talent grant
The article reviews the mechanism of RNAi-based antiviral innate immunity in plants and the counteractions of various viral suppressors of RNA silencing (VSRs). The authors also propose some critical challenges in the field and suggest that further elucidating conserved antiviral innate immunity may provide a broad spectrum of antiviral strategies in the future.
Multiple antiviral immunities were developed to defend against viral infection in hosts. RNA interference (RNAi)-based antiviral innate immunity is evolutionarily conserved in eukaryotes and plays a vital role against all types of viruses. During the arms race between the host and virus, many viruses evolve viral suppressors of RNA silencing (VSRs) to inhibit antiviral innate immunity. Here, we reviewed the mechanism at different stages in RNAi-based antiviral innate immunity in plants and the counteractions of various VSRs, mainly upon infection of RNA viruses in model plant Arabidopsis. Some critical challenges in the field were also proposed, and we think that further elucidating conserved antiviral innate immunity may convey a broad spectrum of antiviral strategies to prevent viral diseases in the future.
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