期刊
VIRUSES-BASEL
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/v14020181
关键词
Acinetobacter; bacteriophages; comparative genomics; phage therapy; bioinformatics
类别
资金
- Portuguese Foundation for Science and Technology [UIDB/04469/2020]
- UK Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Program grant [BB/R012490/1]
- Gut Microbes and Health Research Programme [BBS/E/F/000PR10353, BBS/E/F/000PR10356]
The genetic diversity of Acinetobacter phages was explored using comparative genomics approaches, revealing eight clusters and 46 sub-clusters. Five new subfamilies were proposed, and a reorganisation of the genus Obolenskvirus was suggested. These findings provide updated insights into the viruses infecting Acinetobacter species and their diversity.
The number of sequenced Acinetobacter phage genomes in the International Nucleotide Sequence Database Collaboration has increased significantly in recent years, from 37 in 2017 to a total of 139 as of January 2021 with genome sizes ranging from 31 to 378 kb. Here, we explored the genetic diversity of the Acinetobacter phages using comparative genomics approaches that included assessment of nucleotide similarity, shared gene content, single gene phylogeny, and the network-based classification tool vConTACT2. Phages infecting Acinetobacter sp. are genetically diverse and can be grouped into 8 clusters (subfamilies) and 46 sub-clusters (genera), of which 8 represent genomic singletons (additional genera). We propose the creation of five new subfamilies and suggest a reorganisation of the genus Obolenskvirus. These results provide an updated view of the viruses infecting Acinetobacter species, providing insights into their diversity.
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