期刊
VIRUSES-BASEL
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/v13112143
关键词
Crohn's disease; COVID-19; vaccine; SARS-CoV-2
类别
资金
- Instituto de Tecnologia em Imunobiologicos (Bio-Manguinhos)
- Fundacao Oswaldo Cruz (FIOCRUZ) [BIO-003-FIO-20]
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro [FAPERJSEI-260003/002688/2020]
- Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz [VPPCB-05-FIO-20-2-52]
A study found that Crohn's disease patients may have different humoral and cellular immune responses after COVID-19 vaccination, especially with the role of T-cell immunity in the absence of antibody production. Therefore, it is recommended for Crohn's disease patients to receive COVID-19 vaccines.
Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn's disease patient treated with Infliximab (10 mg/kg); we included comparisons with a monozygotic twin. The results showed that the Crohn's disease's twin (twin 2) had no antibody detection and reduced activation of CD4+ T cell responses, unlike the twin without the autoimmune disease (twin 1). Twin 2 developed antigen-specific central memory CD8+ T-cells and IFN gamma production after the second dose of COVID-19 vaccination, similar to twin 1. These findings elucidated the role of T-cell immunity after COVID-19 immunization on IBD patients despite the lack of antibody production. Finally, our observation supports the consensus recommendation for IBD patients to receive COVID-19 vaccines.
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