期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 35, 期 -, 页码 22-28出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2016.03.020
关键词
Astragaloside IV; Diabetes; Wound healing; Extracellular matrix; Alternatively activated macrophages
资金
- Guangdong Natural Science Foundation [S2012010009409, 2014A030313581, 2015A030313581]
- Joint Natural Sciences Fund of the Department of Science and Technology
- First Affiliated Hospital of Guangdong Pharmaceutical University [GYFYLH201320]
Astragaloside IV (AS-IV), one of the major active compounds extracted from Astragali Radix, has been used experimentally for its potent antiinflammatory and immunoregulatory activities. In this study, we further investigate the potential efficacy of AS-IV on impaired wound healing in streptozotocin-induced diabetic mice. A full-thickness skin wound was produced on the back of diabetic mice and treated with AS-IV or vehicle topically. Our results showed that AS-IV application promoted diabetic wound repair with wounds gaping narrower and exhibiting augmented reepithelialization. AS-IV enhanced the collagen deposition and the expression of extracellular matrix (ECM)-related genes such as fibronectin and collagen IIIa, which implies a direct effect of AS-IV on matrix synthesis. AS-IV also improved the new blood vessel formation in wound tissue with increased numbers of endothelial cells and enhanced expression of VEGF and vWF. Moreover, the beneficial effect of AS-IV was related to the development of polarized alternatively activated macrophages, which involved in resolution of inflammation and facilitation of wound repair. All together, these findings suggest that AS-IV may play a potential effect on maintenance of cutaneous homeostasis and acceleration of diabetic wound healing. (C) 2016 Elsevier B.V. All rights reserved.
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