A metal-organic framework ZJU-136-Ce for combined chemotherapy and chemodynamic therapy

A metal-organic framework ZJU-136-Ce with ideal water stability was synthesized. It was adopted to load Mn2+ and DOX for chemo/chemodynamic therapy of tumor, the loading capacity of Mn2+ and DOX was 0.87 wt % and 10.19 wt % in ZJU-136-Ce, respectively. DOX&Mn@ZJU-136-Ce exhibited significant effects of inhibition of Hela cell growth, which confirmed it had a potential application prospect in the multimodal cancer therapy.

Automated summary

A metal-organic framework ZJU-136-Ce with ideal water stability was synthesized and used to load Mn2+ and DOX for tumor chemo/chemodynamic therapy, showing significant inhibition effects on Hela cell growth. It has potential application prospects in multimodal cancer therapy.