期刊
YONSEI MEDICAL JOURNAL
卷 63, 期 3, 页码 241-251出版社
YONSEI UNIV COLL MEDICINE
DOI: 10.3349/ymj.2022.63.3.241
关键词
Gastrointestinal microbiome; gout; hyperuricemia; uric acid
资金
- Yonsei University College of Medicine [6-2017-0055]
This study reveals differences in microbiota composition between patients with asymptomatic hyperuricemia (asHU) and those with gout. The gut microbiota in asHU patients may have a protective effect against gout development, while in gout patients it may play a role in gout provocation. Uric acid-lowering therapy (ULT) alters the gut microbiota in gout patients, potentially alleviating gout pathology and mitigating gout progression.
Purpose: Here, we aimed to elucidate the differences in microbiota composition between patients with gout and those with asymptomatic hyperuricemia (asHU) and determine the effect of uric acid-lowering therapy (ULT) on the gut microbiome. Materials and Methods: Stool samples from patients with asHU (n=8) and three groups of gout patients, i.e., acute gout patients before ULT (0ULT, n=14), the same acute gout patients after 30-day ULT (30ULT, n=9), and chronic gout patients after >= 6-month ULT (cULT, n=18) were collected and analyzed using 16S rRNA gene-based pyrosequencing. The composition of microbial taxonomy and communities, species diversity, and relationships among microbial communities were elucidated by bioinformatic analysis. Results: Gout patients showed less diverse gut microbiota than asHU patients. The microbiota of the asHU group exhibited a higher Firmicutes-to-Bacteroidetes (F/B) ratio and lower Prevotella-to-Bacteroides (P/B) ratio than the gout group; significantly, the F/B ratio increased in gout patients after ULT. Moreover, a balanced enterotype populated asHU patients compared to gout patients. Notably, the gut microbiota in asHU patients had a higher proportion of taxa with potentially anti-inflammatory effects compared to the gut microbiota in gout patients. Conclusion: We found that microbial composition differs between asHU and gout patients. The differential gut microbiota in asHU patients may protect against gout development, whereas that in gout patients may have a role in gout provocation. ULT in gout patients altered the gut microbiota, and may help alleviate gout pathology and mitigate gout progression.
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