期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 31, 期 -, 页码 32-38出版社
ELSEVIER
DOI: 10.1016/j.intimp.2015.12.010
关键词
Interleukin-17; Allergy; Streptococcus pneumoniae; Airway inflammation
资金
- National Natural Science Foundation of China [12ZR1425700]
- Technology Commission of Shanghai Municipality [10ZR1423000]
Despite decreasing rates of invasive pneumococcal disease caused by vaccine serotypes, the prevalence of invasive pneumococcal pneumonia in asthmatic patients remains high. However, little is known about the mechanisms underlying the susceptibility of the asthmatic airway to bacterial infections. In this study, we used a combined model of allergic airway inflammation and Streptococcus pneumoniae lung infection to investigate the association between persistent allergic inflammation in the airway and antibacterial host defenses against S. pneumoniae. When challenged with S. pneumoniae, allergic mice exhibited higher airway bacterial burdens, greater eosinophil infiltration, lower neutrophil infiltration, and more severe structural damage than non allergic mice. In sensitized mice, S. pneumoniae infection elicited higher IL-4 but lower IFN-gamma, IL-17 and defensin-beta 2 expression than in control mice. These results indicate that persistent allergic inflammation impaired airway host defense against S. pneumoniae is associated with the insufficient IL-17 responses. To elicit IL-17 induced-anti-bacterial immune responses, mice were intranasally immunized with rIL-17. Immunized mice exhibited fewer bacterial colonies in the respiratory tract and less severe lung pathology than unimmunized mice. rIL-17 contributed to airway host defense enhancement and innate immune response promotion, which was associated with increased IL-23, MIP-2 and defensin-beta 2 expression. Administration of exogenous IL-17 (2 mu g/mouse) suppressed eosinophil-related immune responses. The results demonstrate IL-17 plays a key role in host defenses against bacterial infection in allergic airways and suggest that exogenous IL-17 administration promotes the anti-becterial immune responses and attenuates the existed allergic inflammation. (C) 2015 Elsevier B.V. All rights reserved.
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