4.6 Review

Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Stephan B. Dreyer et al.

Summary: DDR deficiency and replication stress are independent of each other, offering opportunities for therapy in DDR-proficient PC and after platinum therapy. Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors, including previously described molecular subtypes, and serve as a valuable model for studying novel therapeutic strategies targeting DDR and replication stress in PC.

GASTROENTEROLOGY (2021)

Article Oncology

Combined Targeting of PARG and Wee1 Causes Decreased Cell Survival and DNA Damage in an S-Phase-Dependent Manner

Lebaron C. Agostini et al.

Summary: The DDR pathway is crucial for tumorigenesis, and therapeutic approaches targeting DDR include enhancing the efficacy of cytotoxic chemotherapies and increasing DNA damage through synergistic drug strategies. Coinhibition of PARG and Wee1 was found to synergistically decrease cell survival and increase DNA damage in an S-phase-dependent manner.

MOLECULAR CANCER RESEARCH (2021)

Article Immunology

CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model

Adam L. Burrack et al.

Summary: Pancreatic cancer is resistant to immunotherapy due to T cell exhaustion, but using a specific immune treatment strategy can overcome this and lead to tumor regression.

JOURNAL OF IMMUNOLOGY (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Pharmacology & Pharmacy

Developing effective combination therapy for pancreatic cancer: An overview

Aubrey L. Miller et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Oncology

Metabolic Alterations in Pancreatic Cancer Progression

Enza Vernucci et al.

CANCERS (2020)

Article Biotechnology & Applied Microbiology

GFAT1/HBP/O-GlcNAcylation Axis Regulates β-Catenin Activity to Promote Pancreatic Cancer Aggressiveness

Chunzeng Jia et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Article Immunology

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

Maria Victoria Recouvreux et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Oncology

Genetic Redirection of T Cells for the Treatment of Pancreatic Cancer

Aesha I. Ali et al.

FRONTIERS IN ONCOLOGY (2019)

Review Oncology

Exploiting DNA Replication Stress for Cancer Treatment

Tajinder Ubhi et al.

CANCER RESEARCH (2019)

Review Oncology

Current Status of Immunotherapies for Treating Pancreatic Cancer

Annie A. Wu et al.

CURRENT ONCOLOGY REPORTS (2019)

Article Cell Biology

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies

Roheena Z. Panni et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Biochemistry & Molecular Biology

Chemoresistance in Pancreatic Cancer

Siyuan Zeng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

Sylvie M. Noordermeer et al.

TRENDS IN CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

miR-9-5p inhibits pancreatic cancer cell proliferation, invasion and glutamine metabolism by targeting GOT1

Juan Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Immunology

Defining 'T cell exhaustion'

Christian U. Blank et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Katherine A. Hoadley et al.

Article Biochemistry & Molecular Biology

MiR-21-mediated Metabolic Alteration of Cancer-associated Fibroblasts and Its Effect on Pancreatic Cancer Cell Behavior

Shuo Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Review Immunology

The Potential of CAR T Cell Therapy in Pancreatic Cancer

Mehmet Akce et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

Naiara Santana-Codina et al.

NATURE COMMUNICATIONS (2018)

Article Oncology

PKM2 is not required for pancreatic ductal adenocarcinoma

Alissandra L. Hillis et al.

CANCER & METABOLISM (2018)

Review Oncology

Cancer metabolism: a therapeutic perspective

Ubaldo E. Martinez-Outschoorn et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Gastroenterology & Hepatology

Hypermutation In Pancreatic Cancer

Jeremy L. Humphris et al.

GASTROENTEROLOGY (2017)

Article Cell Biology

Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells

Hengqiang Zhao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Article Multidisciplinary Sciences

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Prasenjit Dey et al.

NATURE (2017)

Letter Medicine, General & Internal

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

Mark Yarchoan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Multidisciplinary Sciences

Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer

Ru Chen et al.

SCIENTIFIC REPORTS (2017)

Article Cell Biology

Susceptibility of ATM-deficient pancreatic cancer cells to radiation

Michael Ayars et al.

CELL CYCLE (2017)

Article Oncology

Pancreatic Cancer Genomes: Implications for Clinical Management and Therapeutic Development

Stephan B. Dreyer et al.

CLINICAL CANCER RESEARCH (2017)

Article Gastroenterology & Hepatology

PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma

Chenggang Li et al.

DIGESTIVE DISEASES AND SCIENCES (2016)

Review Biochemistry & Molecular Biology

Macrodomains: Structure, Function, Evolution, and Catalytic Activities

Johannes Gregor Matthias Rack et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

Review Biochemistry & Molecular Biology

PKM2, cancer metabolism, and the road ahead

Talya L. Dayton et al.

EMBO REPORTS (2016)

Article Biochemistry & Molecular Biology

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei et al.

MOLECULAR CANCER (2016)

Article Multidisciplinary Sciences

Genomic analyses identify molecular subtypes of pancreatic cancer

Peter Bailey et al.

NATURE (2016)

Article Multidisciplinary Sciences

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Whole genomes redefine the mutational landscape of pancreatic cancer

Nicola Waddell et al.

NATURE (2015)

Article Medicine, General & Internal

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

D. T. Le et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Multidisciplinary Sciences

Adoptive cell transfer as personalized immunotherapy for human cancer

Steven A. Rosenberg et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition

Ronan Russell et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Agnieszka K. Witkiewicz et al.

NATURE COMMUNICATIONS (2015)

Review Oncology

Stromal reengineering to treat pancreas cancer

Ingunn M. Stromnes et al.

CARCINOGENESIS (2014)

Article Biochemistry & Molecular Biology

miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway

Zhonghua Wei et al.

FEBS LETTERS (2014)

Review Immunology

Re-adapting T cells for cancer therapy: from mouse models to clinical trials

Ingunn M. Stromnes et al.

IMMUNOLOGICAL REVIEWS (2014)

Article Medicine, Research & Experimental

Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium

Everett J. Moding et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Multidisciplinary Sciences

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Andrea Viale et al.

NATURE (2014)

Review Biochemistry & Molecular Biology

The recognition and removal of cellular poly(ADP-ribose) signals

Eva Barkauskaite et al.

FEBS JOURNAL (2013)

Article Multidisciplinary Sciences

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son et al.

NATURE (2013)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)

Article Cell Biology

DNA Damage Sensing by the ATM and ATR Kinases

Alexandre Marechal et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Biochemistry & Molecular Biology

DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells

Yuriko Saiki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying et al.

Review Biochemistry & Molecular Biology

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

Robert C. Stanton

IUBMB LIFE (2012)

Article Medicine, General & Internal

Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer

Julie R. Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Biochemical Research Methods

Analysis of cancer metabolism with high-throughput technologies

Aleksandra A. Markovets et al.

BMC BIOINFORMATICS (2011)

Article Oncology

Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase

Nicholas O. Roman et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)

Article Oncology

Glucose Metabolism Gene Variants Modulate the Risk of Pancreatic Cancer

Xiaoqun Dong et al.

CANCER PREVENTION RESEARCH (2011)

Article Biochemical Research Methods

Proteomic Analysis of Pancreatic Ductal Adenocarcinoma Cells Reveals Metabolic Alterations

Weidong Zhou et al.

JOURNAL OF PROTEOME RESEARCH (2011)

Article Medicine, General & Internal

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

Thierry Conroy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Oncology

Regulation of cancer cell metabolism

Rob A. Cairns et al.

NATURE REVIEWS CANCER (2011)

Article Medicine, General & Internal

Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection A Randomized Controlled Trial

John P. Neoptolemos et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)

Review Biochemistry & Molecular Biology

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Raga Krishnakumar et al.

MOLECULAR CELL (2010)

Review Oncology

PARP inhibition: PARP1 and beyond

Michele Rouleau et al.

NATURE REVIEWS CANCER (2010)

Article Biochemistry & Molecular Biology

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Taro Hitosugi et al.

SCIENCE SIGNALING (2009)

Review Biochemistry & Molecular Biology

5-fluorouracil: Mechanisms of resistance and reversal strategies

Ning Zhang et al.

MOLECULES (2008)

Article Multidisciplinary Sciences

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk et al.

NATURE (2008)

Article Gastroenterology & Hepatology

Molecular genetics of pancreatic intraepithelial neoplasia

Georg Feldmann et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY (2007)

Review Oncology

Tumor-stroma interactions in pancreatic ductal adenocarcinoma

Daruka Mahadevan et al.

MOLECULAR CANCER THERAPEUTICS (2007)

Article Oncology

Cellular pharmacology of gemcitabine

E. Mini et al.

ANNALS OF ONCOLOGY (2006)

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)

Article Oncology

Prognostic factors in pancreatic carcinoma - Serum LDH levels predict survival in metastatic disease

F Tas et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2001)