期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 38, 期 -, 页码 443-449出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2016.06.026
关键词
Caffeic acid; Ferulic acid; Coumaric add; Interferon-gamma; Interleukin-2; CD25
资金
- Japan Society for the Promotion of Science (JSPS) [15K18701]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Supported Program for the Strategic Research Foundation at Private Universities [S1512002]
- Grants-in-Aid for Scientific Research [15K18701] Funding Source: KAKEN
Recent studies have revealed that lignin-like polymerized polyphenols can activate innate immune systems. In this study, we aimed to evaluate whether these polymerized polyphenols could activate leukocytes from different murine strains. Splenocytes from 12 mouse strains were investigated. Our results revealed species differences in reactivity to phenolic polymers on interferon-gamma (IFN-gamma) release. Mice that possessed the H2(a) or H2(k) haplotype antigens were the highly responsive strains. To clarify these different points in soluble factors, multiplex cytokine profiling analysis was carried out and we identified interleukin (IL)-2 as a key molecule for IFN-gamma induction by polymerized polyphenols. Furthermore, inhibition of IL-2 and IL-2R alpha by neutralizing antibodies significantly decreased cytokine production in the highly responsive mice strains. Our results indicate that species difference in reactivity to phenolic polymers is mediated by adequate release of IL-2 and its receptor, IL-2R alpha. (C) 2016 Elsevier B.V. All rights reserved.
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