相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
Christoph Fraune et al.
ANNALS OF SURGICAL ONCOLOGY (2020)
Tumor Immunology and Tumor Evolution: Intertwined Histories
Jerome Galon et al.
IMMUNITY (2020)
BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
Bruno Bockorny et al.
NATURE MEDICINE (2020)
Immunotherapy for pancreatic cancer: A 2020 update
Dimitrios Schizas et al.
CANCER TREATMENT REVIEWS (2020)
The Immune Microenvironment in Pancreatic Cancer
Magdalena Huber et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study
Mark H O'Hara et al.
LANCET ONCOLOGY (2020)
Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis
Tuyen Thuy Bich Ho et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)
CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration
Ronghua Zhang et al.
JOURNAL OF CANCER (2020)
Activated pancreatic stellate cells inhibit NK cell function in the human pancreatic cancer microenvironment
Qiang Huang et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2019)
Evaluation of safety and efficacy of p53MVA vaccine combined with pembrolizumab in patients with advanced solid cancers
V. Chung et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2019)
Neutrophil Degranulation, Plasticity, and Cancer Metastasis
Faustino Mollinedo
TRENDS IN IMMUNOLOGY (2019)
Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study)
Dung T. Le et al.
CLINICAL CANCER RESEARCH (2019)
The Tumor Microenvironment Innately Modulates Cancer Progression
Dominique C. Hinshaw et al.
CANCER RESEARCH (2019)
Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer
Talia Golan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients
Seon Ah Lim et al.
FRONTIERS IN IMMUNOLOGY (2019)
Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial
Eileen M. O'Reilly et al.
JAMA ONCOLOGY (2019)
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3
Rosalinda Trovato et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)
Strategies in Developing Immunotherapy for Pancreatic Cancer: Recognizing and Correcting Multiple Immune Defects in the Tumor Microenvironment
Sireesha Upadhrasta et al.
JOURNAL OF CLINICAL MEDICINE (2019)
Tumour response to TRK inhibition in a patient with pancreatic adenocarcinoma harbouring an NTRK gene fusion
E. M. O'Reilly et al.
ANNALS OF ONCOLOGY (2019)
Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches
Anita Thyagarajan et al.
CANCERS (2019)
Independent effect of postoperative neutrophil-to-lymphocyte ratio on the survival of pancreatic ductal adenocarcinoma with open distal pancreatosplenectomy and its nomogram-based prediction
Ning Pu et al.
JOURNAL OF CANCER (2019)
Phase Ib/II study of gemcitabine, nab-paclitaxel, and pembrolizumab in metastatic pancreatic adenocarcinoma
Glen J. Weiss et al.
INVESTIGATIONAL NEW DRUGS (2018)
Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers
Kaichao Feng et al.
PROTEIN & CELL (2018)
Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations
Zishuo I. Hu et al.
CLINICAL CANCER RESEARCH (2018)
Landscape of Tumor Mutation Load, Mismatch RepairDeficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers
Mohamed E. Salem et al.
MOLECULAR CANCER RESEARCH (2018)
Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
Andrew J. Aguirre et al.
CANCER DISCOVERY (2018)
New Insights Into the Regulation of γδ T Cells by BTN3A and Other BTN/BTNL in Tumor Immunity
Juan-Luis Blazquez et al.
FRONTIERS IN IMMUNOLOGY (2018)
FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer
T. Conroy et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Immunotherapy and pancreatic cancer: unique challenges and potential opportunities
Kate Young et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)
Immunotherapy for pancreatic cancer: Barriers and breakthroughs
Robert J. Torphy et al.
ANNALS OF GASTROENTEROLOGICAL SURGERY (2018)
Natural killer cells and other innate lymphoid cells in cancer
Laura Chiossone et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
Kyaw L. Aung et al.
CLINICAL CANCER RESEARCH (2018)
Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer
David Balli et al.
CLINICAL CANCER RESEARCH (2017)
Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape
Leisha A. Emens et al.
EUROPEAN JOURNAL OF CANCER (2017)
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Dung T. Le et al.
SCIENCE (2017)
Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression
Laura Pinton et al.
ONCOTARGET (2016)
Pancreatic cancer: Update on immunotherapies and algenpantucel-L
Kinsey A. McCormick et al.
HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)
Regulatory T cells that co-express RORt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer
Stalin Chellappa et al.
ONCOIMMUNOLOGY (2016)
The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases
Kota Arima et al.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2016)
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey et al.
NATURE (2016)
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Kristen E. Pauken et al.
SCIENCE (2016)
The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer
Hai Hu et al.
TUMOR BIOLOGY (2016)
Epidemiology of pancreatic cancer
Milena Ilic et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2016)
Preoperative neutrophil-to-lymphocyte ratio and tumor-related factors to predict lymph node metastasis in patients with pancreatic ductal adenocarcinoma (PDAC)
Lianyuan Tao et al.
ONCOTARGET (2016)
Pancreatic cancer
Jorg Kleeff et al.
NATURE REVIEWS DISEASE PRIMERS (2016)
Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer
Clifford J. Whatcott et al.
CLINICAL CANCER RESEARCH (2015)
Stromal biology and therapy in pancreatic cancer: a changing paradigm
Albrecht Neesse et al.
GUT (2015)
Phase II, randomized study of GVAX pancreas and CRS-207 immunotherapy in patients with metastatic pancreatic cancer: Clinical update on long term survival and biomarker correlates to overall survival.
Chan Whiting et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
Richard A. Moffitt et al.
NATURE GENETICS (2015)
Immune Escape Mechanisms as a Guide for Cancer Immunotherapy
Gregory L. Beatty et al.
CLINICAL CANCER RESEARCH (2015)
A phase I dose escalation trial of tremelimumab (CP-675,206) in combination with gemcitabine in chemotherapy-naive patients with metastatic pancreatic cancer
M. Aglietta et al.
ANNALS OF ONCOLOGY (2014)
Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction
Yun-Peng Peng et al.
BMC CANCER (2014)
Tumour-stroma interactions in pancreatic ductal adenocarcinoma: Rationale and current evidence for new therapeutic strategies
V. Heinemann et al.
CANCER TREATMENT REVIEWS (2014)
IRF4 at the crossroads of effector T-cell fate decision
Magdalena Huber et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2014)
Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial
Gary Middleton et al.
LANCET ONCOLOGY (2014)
Exomics and immunogenics Bridging mutational load and immune checkpoints efficacy
Stephane Champiat et al.
ONCOIMMUNOLOGY (2014)
Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
Y. Ino et al.
BRITISH JOURNAL OF CANCER (2013)
Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients
Hidekazu Kameshima et al.
CANCER SCIENCE (2013)
Inflammatory networks and immune surveillance of pancreatic carcinoma
Robert H. Vonderheide et al.
CURRENT OPINION IN IMMUNOLOGY (2013)
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
Bernd H. Zinselmeyer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Evaluation of Ipilimumab in Combination With Allogeneic Pancreatic Tumor Cells Transfected With a GM-CSF Gene in Previously Treated Pancreatic Cancer
Dung T. Le et al.
JOURNAL OF IMMUNOTHERAPY (2013)
Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic cancer
Shingo Asahara et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2013)
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov et al.
NATURE (2013)
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Daniel D. Von Hoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
Christine Feig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
Jennifer Watt et al.
ONCOIMMUNOLOGY (2013)
Expanding roles for CD4T cells and their subpopulations in tumor immunity and therapy
Mark J. Dobrzanski
FRONTIERS IN ONCOLOGY (2013)
Pancreatic adenocarcinoma: ESMO-ESDO Clinical Practice Guidelines for diagnosis, treatment and follow-up
T. Seufferlein et al.
ANNALS OF ONCOLOGY (2012)
Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent
Skye C. Mayo et al.
CANCER (2012)
The Pancreas Cancer Microenvironment
Christine Feig et al.
CLINICAL CANCER RESEARCH (2012)
Effect of Pemetrexed on Innate Immune Killer Cells and Adaptive Immune T Cells in Subjects With Adenocarcinoma of the Pancreas
Marcherie Davis et al.
JOURNAL OF IMMUNOTHERAPY (2012)
Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation
Nikolaos Patsoukis et al.
SCIENCE SIGNALING (2012)
Potential plasticity of T regulatory cells in pancreatic carcinoma in relation to disease progression and outcome
Barbara Vizio et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2012)
A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation
Eric Lutz et al.
ANNALS OF SURGERY (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
Lucia De Monte et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Personalized dendritic cell-based tumor immunotherapy
Nona Janikashvili et al.
IMMUNOTHERAPY (2010)
Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma
Richard E. Royal et al.
JOURNAL OF IMMUNOTHERAPY (2010)
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Subhra K. Biswas et al.
NATURE IMMUNOLOGY (2010)
Pancreatic Cancer
Manuel Hidalgo
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
F. Stephen Hodi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer
Carolyn E. Clark et al.
CANCER LETTERS (2009)
Carcinoembryonic Antigen-Specific but Not Antiviral CD4+ T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients
Elena Tassi et al.
JOURNAL OF IMMUNOLOGY (2008)
Exploring the full spectrum of macrophage activation
David M. Mosser et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer
Howard L. Kaufman et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2007)
Pancreatic cancer microenvironment
Joerg Kleeff et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
S. L. Bernhardt et al.
BRITISH JOURNAL OF CANCER (2006)
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinorna and its premalignant lesions
Nobuyoshi Hiraoka et al.
CLINICAL CANCER RESEARCH (2006)
Emerging possibilities in the development and function of regulatory T cells
Kajsa Wing et al.
INTERNATIONAL IMMUNOLOGY (2006)
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
B Huang et al.
CANCER RESEARCH (2006)
Paradoxical roles of the immune system during cancer development
KE de Visser et al.
NATURE REVIEWS CANCER (2006)
Immunotherapy for pancreatic cancer - Science driving clinical progress
D Laheru et al.
NATURE REVIEWS CANCER (2005)
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
TJ Curiel et al.
NATURE MEDICINE (2004)
CD8(+) tumor-infiltrating lymphocytes together with CD4(+) tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma
A Fukunaga et al.
PANCREAS (2004)
A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
J Wyckoff et al.
CANCER RESEARCH (2004)
Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity
C Melani et al.
BLOOD (2003)
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant:: Clinical and immunological responses in patients with pancreatic adenocarcinoma
MK Gjertsen et al.
INTERNATIONAL JOURNAL OF CANCER (2001)
Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells
DI Gabrilovich et al.
JOURNAL OF IMMUNOLOGY (2001)
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
GJ Freeman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
分享论文
