期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 23, 期 4, 页码 307-317出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2021.1988703
关键词
Suicide attempt; inflammation; IL-6; attention; trauma
类别
资金
- Carlos III Health Research Institute [PI15/00789, PI17/01433, PI18/01055, PI19/00569]
- European Regional Development Fund (ERDF)/European Social Fund 'Investing in your future'
- Government of the Principality of Asturias [PCTI-2018-2022 IDI/2018/235]
- Basque Government [2017111104]
- University of the Basque Country [321218ELCY]
- Stanley Research Foundation [03-RC-003]
The study found that IL-6 levels are associated with suicidal behavior, which may be influenced by stressful and traumatic experiences. Elevated concentrations of IL-6 could have a negative impact on attention, increasing the risk of suicide.
Objectives To explore the link between cytokines and suicide attempts and their relationship with the psychological aspects of this complex multifactorial phenomenon. Methods 96 participants, including 20 patients with a recent suicide attempt and diagnosis of Major Depression Disorder (MDD), 33 MDD patients with a lifetime history of suicide attempt, 23 non-attempter MDD patients, and 20 healthy controls underwent an assessment on depressive symptoms, global functioning, aggressive behaviour, presence of abuse and attention performance. Additionally, all participants had a blood extraction for IL-2, IL2-R, IL-4, IL-6, and TNF-alpha plasma levels analysis. Results IL-6 levels were significantly different across groups (F(3,89)=3.690; p = 0.015), with higher concentrations in both recent (p = 0.04) and distant (p = 0.015) attempt in comparison to MDD non-attempters. IL-6 was associated with adult physical abuse (B = 2.591; p = 0.021), lower global functioning score (B = -0.512; p = 0.011), and poorer performance on attention (B = -0.897; p = 0.011). Conclusions Recent and distant suicidal behaviour is associated with elevated IL-6 levels, which may be influenced by stressful and traumatic experiences. Elevated concentrations of IL-6 could have a negative impact on attention, increasing suicide risk. More research is needed to clarify the role of cytokines in suicide-related features to explore novel treatments and more effective preventive interventions.
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