期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 23, 期 7, 页码 560-571出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2021.2014683
关键词
Paedophilic disorder; randomised clinical trial; sexual desire; compulsive sexual behaviour disorder; age of onset
类别
资金
- Fredrik och Ingrid Thurings Stiftelse
- Research Unit of Skaraborg Hospital
- Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet
- Swedish government
- Swedish country councils
- Stiftelsen Soderstrom Konigska Sjukhemmet
- Svenska Lakaresallskapet
This study examined the effects of testosterone suppression from degarelix on desire, hypersexuality, and subjectively experienced sexual interest in participants with paedophilic disorder. Results showed that degarelix treatment significantly decreased sexual desire and reduced sexual interest in children, regardless of other traits and individual factors.
Effects of testosterone withdrawal on significant correlates of paedophilic disorder (PeD) are largely unknown. The purpose of this study was to explore in detail the effects of testosterone suppression from degarelix as compared to placebo on desire, hypersexuality, and subjectively experienced sexual interest in participants with PeD. We compared the sexual effects of degarelix, a GnRH antagonist, on men with PeD assigned to degarelix (n = 26) or placebo (n = 26) in a double-blind randomised clinical trial. Sexual Desire Inventory scores decreased significantly at two weeks (between-group difference p = 0.001, d = -0.96 [-0.38 to -1.55) and ten weeks (p < 0.001, d = -1.30 [-0.69 to -1.91) in participants assigned degarelix, whereas HBI ratings did not differ significantly at two weeks (p = 0.07, d = -0.52 [0.05 to -1.08), but did so at ten weeks (p = 0.01, d = -0.72 [-0.15 to -1.29). Fifteen out of 26 (58%) individuals in the group assigned degarelix and 3 out of 26 (12%) in the group assigned to placebo reported no further sexual interest in children at ten weeks (Fisher's exact test, p < 0.0001), an effect unmodified by autistic, antisocial, or impulsive traits, age, age at onset of, or duration of paedophilic attraction.
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