期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 34, 期 -, 页码 53-59出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2016.02.011
关键词
Ginsenoside Rg3 (GRg3); Acute lung injury (AU); Lipopolysaccharide (LPS); Nuclear factor-kappa B (NF-kappa B); Cyclooxygenase 2 (COX-2)
Ginsenoside Rg3 (GRg3), one of the major active saponins isolated from ginseng (the root of Panax ginseng C.A. Meyer, Araliaceae), has been reported with many health benefits. Currently, the protective effect of GRg3 on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice was investigated. The results indicated that GRg3 treatment could greatly attenuate LPS-induced histopathological alterations in the lung in a concentration-dependent manner. LPS-induced increase of lung wet-to-dry weight ratio (W/D ratio) was also dose-dependently reduced by GRg3 treatment. LPS-induced increases of the total cells, neutrophils and macrophages in the bronchoalveolar lavage fluids (BALF5) were significantly inhibited by GRg3 treatment in a dose dependent fashion. The levels of pro-inflammatory cytokines including TNF-alpha, IL-1 beta and IL-6 in BALFs increased after LPS-induced ALI, which was inhibited by GRg3. Western blot results showed that during ALI LPS activated NF-kappa B pathway in the lung tissues by upregulating NF-kappa B p65 phosphorylation and its downstream COX-2 expression; however, these effects of LPS were inhibited by GRg3 treatment. Taken together, these findings in present study suggested that GRg3 provided protective effects against LPS-induced ALI in animal model and might harbor the potential to be considered as drug for the treatment of ALI in clinic. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据