期刊
INTERNATIONAL HEART JOURNAL
卷 57, 期 6, 页码 663-671出版社
INT HEART JOURNAL ASSOC
DOI: 10.1536/ihj.16-414
关键词
Atherosclerosis; Type 2 diabetes
资金
- Japan Society for the Promotion of Science KAKENHI [24591114]
- Takeda Scientific Foundation
- Mochida Memorial Foundation
- Suzuken Memorial Foundation
- Senshin Medical Research Foundation
- Yakult Bioscience Research Foundation
- Uehara Memorial Foundation
- Hyogo Science and Technology Association
- Japanese Circulation Society Translational Research Foundation
Gut microbiota have been attracting increased attention in many fields of medicine recently. We can perform a comprehensive analysis of gut microbiota using next-generation sequencing techniques together with bioinformatics technology, which expands our knowledge of a large ecosystem consisting of a host and gut microbiota. We summarize some reports about the correlations between gut microbiota and metabolic disorders, particularly atherosclerosis, and discuss future directions for the diagnostic or therapeutic potential of gut microbiota. To take simple examples, we demonstrated that the order Lactobacillales was significantly increased; while the phylum Bacteroidetes was significantly decreased in coronary artery disease (CAD) patients compared with controls or healthy volunteers. The characteristics of gut microbiota in type 2 diabetes and dyslipidemia have been reported. However, these studies have limitations, and the biological significance of gut microbiota and the causal relationships are still controversial. We hope the reports listed in this review article might lead to the development of a novel therapy to prevent CAD via modulating gut microbiota or their metabolites.
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