COVID-19 convalescent plasma: Evolving strategies for serological screening in France

Article Medical Laboratory Technology

Evaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test

Antonin Bal et al.

Summary: The study found that the Wantai Total Ab assay targeting the receptor binding domain (RBD) within the S protein showed the best sensitivity at different stages of the disease. With the exception of the Euroimmun IgA assay, all other tests had clinical specificity greater than 95%. Some commercial serological assays demonstrated better agreement with the VNT compared to others, but they cannot replace the VNT for assessing functional antibody response.

CLINICAL CHEMISTRY (2021)

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Article Medicine, General & Internal

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

R. Libster et al.

Summary: A randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against SARS-CoV-2 in older adult patients within 72 hours after the onset of mild Covid-19 symptoms found that early administration of high-titer convalescent plasma reduced the progression of Covid-19 in mildly ill infected older adults.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19

M. J. Joyner et al.

Summary: This study found that higher anti-SARS-CoV-2 IgG antibody levels in convalescent plasma were associated with a lower risk of death among patients hospitalized with Covid-19 who were not receiving mechanical ventilation. The association between antibody levels and mortality risk was moderated by mechanical ventilation status, with no significant effect seen in patients who had already received ventilation.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Microbiology

Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina

Diego S. Ojeda et al.

Summary: We developed and applied a robust serologic test in Argentina for evaluating antibody responses to SARS-CoV-2. The test, COVIDAR IgG and IgM, have been widely distributed and used for assessing immune responses, convalescent plasma programs, and large seroprevalence studies. The study provided valuable insights into antibody kinetics in infected individuals and supported policy-making for managing the pandemic.

PLOS PATHOGENS (2021)

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Article Multidisciplinary Sciences

mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

Leonidas Stamatatos et al.

Summary: The study found that vaccination of both previously infected individuals and those who were not infected resulted in increased neutralizing antibody titers, with previously infected individuals showing a greater boost in neutralizing titers. Vaccination of naive individuals also elicited cross-neutralizing responses, but at lower titers.

SCIENCE (2021)

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Article Infectious Diseases

SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data

Dung Nguyen et al.

Summary: The research compared the performance of SARS-CoV-2 neutralising antibody testing among 12 European laboratories involved in convalescent plasma trials. It was found that there were significant differences in titres between laboratories during blind-testing, but calibration of titres reduced this variability. Harmonisation of neutralising antibody quantification is a crucial step towards determining protective and therapeutic levels of neutralising antibodies.

EUROSURVEILLANCE (2021)

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Article Hematology

Assessment of serological assays for identifying high titer convalescent plasma

Christopher W. Farnsworth et al.

Summary: This study aimed to establish correlations and analogous cutoffs between different serological assays, finding relationships between various assays and determining the best correlative index for establishing high-titer units. The results help reconcile the large body of serological data generated during the COVID-19 pandemic, providing insights into the relationships between different assays and their ability to distinguish high-titer specimens.

TRANSFUSION (2021)

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Article Medicine, General & Internal