4.5 Article

Platelet-derived sCD40L: specific inflammatory marker for early-stage severe acute respiratory syndrome coronavirus 2 infection

期刊

VIROLOGY JOURNAL
卷 18, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12985-021-01680-3

关键词

Platelets; Innate immunity; CD40L; Inflammation; SARS-CoV2

类别

资金

  1. French National Blood Service-EFS
  2. CFTR2 (COVID Fast Track Research Rennes) grant from the University hospital of Rennes, France

向作者/读者索取更多资源

The study identified that plasma levels of platelet soluble (s)CD40L are elevated in the early stages of COVID-19, then decrease over time while sCD62P levels increase significantly. These platelet markers could serve as monitoring biomarkers of patient inflammatory state during the disease course.
Background: The SARS-CoV-2 virus is the causing agent of the Coronavirus disease 2019 (COVID-19) characterized by a huge pro-inflammatory response and coagulation disorders that may lead to for its severe forms, in organ failure or even death. As major players of thrombo-inflammation, platelets release large amounts of immunomodulatory molecules and regulate leukocyte and endothelial activity, which are both altered in COVID-19. Altogether, this makes platelets a very likely actor of the thrombo-inflammatory complications of COVID-19. Thus, we propose to identify a platelet inflammatory signature of severe COVID-19 specifically modulated throughout the course of the disease. Methods: Luminex technology and enzyme-linked immunosorbent assay were used to assess plasma levels of platelet inflammatory markers in patients with severe acute respiratory syndrome coronavirus 2 infection on admission and for 14 days afterwards. Results: In accordance with the observations of other teams, we evidence that the plasma levels of the platelet soluble (s)CD40L is significantly elevated in the early stages of the disease. Interestingly we observe that the plasma level of sCD40L decreases overtime while that of sCD62P increases significantly. Conclusions: Our data suggest that there is a platelet signature of inflammatory response to SARS-COv-2 infection which varies overtime and could serve as monitoring biomarkers of patient inflammatory state.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据