期刊
VIROLOGY
卷 562, 期 -, 页码 1-8出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2021.06.010
关键词
Bovine leukemia virus; Violaceoid E; Antiviral activity; Chemical compound; Tax protein; Transcription; Antiviral drugs
类别
资金
- Ito Foundation (Tokyo, Japan)
- Azabu University Research Services Division
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) Supported Program for the Private University Research Branding Project, 2016-2019
- Center for Human and Animal Symbiosis Science, Azabu University
- JSPS KAKENHI [19K06410]
- Grants-in-Aid for Scientific Research [19K06410] Funding Source: KAKEN
The study found that a compound vioE isolated from fungus can inhibit the transcriptional activity of bovine leukemia virus (BLV), suggesting a novel target for the development of anti-BLV drugs by interfering with the virus's transcriptional activation.
Bovine leukemia virus (BLV) infection has spread worldwide causing significant economic losses in the livestock industry. In countries with a high prevalence of BLV, minimizing economic losses is challenging; thus, research into various countermeasures is important for improving BLV control. Because anti-BLV drugs have not been developed, the present study explored a promising chemical compound with anti-BLV activity. Initially, screening of a chemical compound library revealed that violaceoid E (vioE), which is isolated from fungus, showed antiviral activity. Further analysis demonstrated that the antiviral effect of vioE inhibited transcriptional activation of BLV. Cellular thermal shift assay and pulldown assays provided evidence for a direct interaction between vioE and the viral transactivator protein, Tax. These data indicate that interference with Tax-dependent transcription could be a novel target for development of anti-BLV drugs. Therefore, it is suggested that vioE is a novel antiviral compound against BLV.
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