期刊
VIROLOGY
卷 562, 期 -, 页码 176-189出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2021.07.013
关键词
Bobcat; Puma; Caracal; Canada lynx; Domestic cat; Torque teno virus; Anelloviridae
类别
资金
- National Park Service
- Santa Monica Moun-tains Fund
- NSF
- Cape Leopard Trust
- Claude Leon Foundation
- Primero Conservation
- Internal Fondsen KU Leuven/Internal Funds KU Leuven [C14/18/094]
- Research Foundation-Flanders (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen) [G0E1420 N, G098321 N]
Anellovirus infections are highly prevalent in mammals, with diverse anellovirus genomes identified in pumas, bobcats, Canada lynx, caracals, and domestic cats. Phylogenetic analysis revealed two distinct clusters of felid-derived anellovirus sequences, indicating a long coevolution history. Coinfections of diverse anelloviruses are common among felids, with evidence of recombination within and between felid-specific anellovirus groups.
Anellovirus infections are highly prevalent in mammals, however, prior to this study only a handful of anellovirus genomes had been identified in members of the Felidae family. Here we characterise anelloviruses in pumas (Puma concolor), bobcats (Lynx rufus), Canada lynx (Lynx canadensis), caracals (Caracal caracal) and domestic cats (Felis catus). The complete anellovirus genomes (n = 220) recovered from 149 individuals were diverse. ORF1 protein sequence similarity network analysis coupled with phylogenetic analysis, revealed two distinct clusters that are populated by felid-derived anellovirus sequences, a pattern mirroring that observed for the porcine anelloviruses. Of the two-felid dominant anellovirus groups, one includes sequences from bobcats, pumas, domestic cats and an ocelot, and the other includes sequences from caracals, Canada lynx, domestic cats and pumas. Coinfections of diverse anelloviruses appear to be common among the felids. Evidence of recombination, both within and between felid-specific anellovirus groups, supports a long coevolution history between host and virus.
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