期刊
VETERINARY PATHOLOGY
卷 59, 期 2, 页码 186-210出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/03009858211052659
关键词
brain diseases; foodborne diseases; listeriosis; cattle; sheep; goats; bacterial infections; zoonosis; One Health
The article summarizes the association of Listeria monocytogenes with the environment, farm animals, and disease, highlighting its heterogeneity and adaptability. It focuses on the pathology and (molecular) pathogenesis of listeriosis in naturally susceptible species, with a special emphasis on ruminants and the neuroinvasive form of the disease.
The bacterium Listeria monocytogenes (Lm) is widely distributed in the environment as a saprophyte, but may turn into a lethal intracellular pathogen upon ingestion. Invasive infections occur in numerous species worldwide, but most commonly in humans and farmed ruminants, and manifest as distinct forms. Of those, neuroinfection is remarkably threatening due to its high mortality. Lm is widely studied not only as a pathogen but also as an essential model for intracellular infections and host-pathogen interactions. Many aspects of its ecology and pathogenesis, however, remain unclear and are rarely addressed in its natural hosts. This review highlights the heterogeneity and adaptability of Lm by summarizing its association with the environment, farm animals, and disease. It also provides current knowledge on key features of the pathology and (molecular) pathogenesis of various listeriosis forms in naturally susceptible species with a special focus on ruminants and on the neuroinvasive form of the disease. Moreover, knowledge gaps on pathomechanisms of listerial infections and relevant unexplored topics in Lm pathogenesis research are highlighted.
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