期刊
VETERINARNI MEDICINA
卷 67, 期 3, 页码 156-162出版社
CZECH ACADEMY AGRICULTURAL SCIENCES
DOI: 10.17221/212/2020-VETMED
关键词
cryptosporidiosis; diarrhoea; goat; histopathology; phylogenetic analysis; zoonosis
资金
- Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea [N-1543069-2015-99-01]
This study reports on two cases of severe cryptosporidiosis in goat kids in the Republic of Korea. The cases were diagnosed with cryptosporidiosis based on histopathological analysis, genetic subtype analysis, and detection of the parasite. The findings highlight the importance of continuous monitoring and prevention of C. parvum infections in goats for reducing economic losses and maintaining public health safety standards.
Cryptosporidium parvum is an enteric protozoan, which causes severe diarrhoea in a wide range of vertebrate hosts including ruminants and humans. C. parvum infections are responsible for immense economic losses to the livestock industry; furthermore, the zoonotic spread of the infection may lead to mortality in immunosuppressed humans. In the present study, we report two cases of severe cryptosporidiosis in goat kids in the Republic of Korea. Both cases were afflicted with severe diarrhoea upon presentation; the histopathological examinations revealed atrophied and fused intestinal villi and numerous circular basophilic organisms in the jejunum and ileum. Both cases were diagnosed with cryptosporidiosis based on the results of the histopathological analysis, amplification of the C. parvum gp60 gene, modified Ziehl-Neelsen staining, and C. parvum antigen ELISA. According to the phylogenetic analysis using the C. parvum gp60 gene for the genetic subtypes, the C. parvum isolates were identified as subtype IIdA15G1 with zoonotic potential. This is the first pathological report of caprine cryptosporidiosis induced by C. parvum subtype IId in the Republic of Korea. Considering the clinical manifestations associated with the pathological lesions and the zoonotic significance of these findings, the continuous monitoring and prevention of C. parvum infections in goats are essential for minimising the economic losses in ruminant farms and in maintaining public health safety standards.
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