4.1 Article

Comparison of Urine Flow Cytometry on the UF-1000i System and Urine Culture of Urine Samples from Urological Patients

期刊

UROLOGIA INTERNATIONALIS
卷 106, 期 8, 页码 858-867

出版社

KARGER
DOI: 10.1159/000520166

关键词

Urine flow cytometry; Fast urine diagnostic; Infection control; Presurgical screening; Urinary tract infections; Bacteriuria

资金

  1. Deutsches Zentrum fur Infektionsforschung (DZIF)

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The study showed that UFC is an effective tool for detecting significant bacteriuria in urological patients and generally provides high accuracy in comparison to urine culture and dipstick analysis.
Introduction: The aims of this study were to evaluate urine flow cytometry (UFC) as a tool to screen urine samples of urological patients for bacteriuria and to compare UFC and dipstick analysis with urine culture in a patient cohort at a urological department of a university hospital. Methods and Material: We screened 662 urine samples from urological patients (75.2% male; 80.7% inpatients; mean age 58 years). UFC results were compared to microbiological urine culture. Results: The accuracy in using the UFC-based parameters for detecting cultural bacteriuria was 91.99% and 88.97% for >= 10(5) colony-forming units (CFU)/mL and >= 10(4) CFU/mL, respectively. UFC and leukocyte dipstick analysis measured leukocyturia similarly (Pearson correlation coefficient 0.87, p value <0.01%), but dipstick analysis scored less accurately on bacteriuria (accuracy 59.37% and 62.69%). UFC remained effective in subgroup analysis of patients of both sexes and with different urological conditions with its overall use only slightly impaired when assessing gross hematuria (NPV 84.62% for >= 10(4) CFU/mL). UFC also reliably removed those urine samples below cutoffs with negative predictive values of 99.28% for >= 10(5) CFU/mL and 95.86% for >= 10(4) CFU/mL. Conclusion: Counting bacteria with UFC is an accurate and rapid method to determine significant bacteriuria in urological patients and is superior to dipstick analysis or indirect surrogate parameters such as leukocyturia. When UFC is available, we recommend it to be used for the diagnosis of bacteriuria over findings obtained by dipstick analysis.

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