4.7 Article

Nanoencapsulation of hydroxytyrosol in chitosan crosslinked with sodium bisulfate tandem ultrasonication: Techno-characterization, release and antiproliferative properties

期刊

ULTRASONICS SONOCHEMISTRY
卷 82, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.ultsonch.2021.105900

关键词

Nanoencapsulation; Hydroxytyrosol; Chitosan; Ionic gelation; Targeted delivery

资金

  1. Council of Scientific & In-dustrial Research (CSIR) New Delhi, India [09/251/ (0070) /2K17]

向作者/读者索取更多资源

This research investigated the production of chitosan nanocapsules for encapsulating hydroxytyrosol. The resulting nanocapsules exhibited favorable packaging characteristics and encapsulation efficiency, and showed superior antioxidant and antiproliferative properties compared to free hydroxytyrosol.
This research includes production of chitosan nanocapsules through ionic gelation with sodium bisulfate for nanoencapsulation of hydroxytyrosol (HT) using ultrasonication in tandem. The resulting nanocapsules encapsulating HT were analyzed for particle size, zeta-potential, packaging characteristics, FESEM, ATR-FTIR, XRD, DSC, in vitro release, antioxidant potential and antiproliferative properties. The nanocapsules (size 119.50-365.21 nm) were spherical to irregular shaped with positive zeta-potential (17.50-18.09 mV). The encapsulation efficiency of 5 mg/g HT (HTS1) and 20 mg/g HT (HTS2) was 77.13% and 56.30%, respectively. The nanocapsules were amorphous in nature with 12.34% to 15.48% crystallinity and crystallite size between 20 nm and 27 nm. Formation of nanocapsules resulted in increasing the glass transition temperature. HTS2 delivered 67.12% HT (HTS1 58.89%) at the end of the simulated gastrointestinal digestion. The nanoencapsulated HT showed higher antioxidant and antiproliferative (against A549 and MDA-MB-231 cancer cell lines) properties than the free HT.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据