期刊
ULTRASONICS SONOCHEMISTRY
卷 83, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ultsonch.2022.105946
关键词
Glycyrrhiza glabra; Deep eutectic solvents; Ultrasound-assisted extraction; Glabridin; Isoliquiritigenin; Molecular dynamic simulation
资金
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2020098]
- China Postdoctoral Science Foundation [2020M670877]
- Key Research and Development Program of Heilongjiang Province [GA21B006]
- China Agriculture Research System of MOF
- China Agriculture Research System of MARA
In this study, an eco-friendly deep eutectic solvent (NADESs) based ultrasound assisted extraction (DES-UAE) method was used to prepare high-quality licorice extracts with higher contents of glabridin (GLA) and isoliquiritigenin (ISL) and superior pharmacological activities. The mechanism of the increased extraction efficacy was also investigated.
Licorice (Glycyrrhiza glabra) is extensively used owing to the superior pharmacological effects. However, its maximum application potential has not been fully exploited due to the limitation of currently available extraction solvent and methods. In this study, an eco-friendly deep eutectic solvent (NADESs) based ultrasound assisted extraction (DES-UAE) method was applied to prepare licorice extracts. The DES-UAE using choline chloride and lactic acid as solvent was optimized and modeled by using response surface methodology to maximize the extraction yields of glabridin (GLA) and isoliquiritigenin (ISL). The optimized extracts possessed higher contents of GLA and ISL than available extraction methods, and the enriched products showed superior pharmacological activities in vitro. Furthermore, scanning electron microscopy (SEM) and molecular dynamic simulation analyses were performed to deeply investigate the interaction between solvent and targeted compounds. This study not only provides an eco-friendly method for high-efficient extraction of GLA and ISL from licorice but also illustrates the mechanism of the increased extraction efficacy, which may contribute to the application of licorice and deep insight into extraction mechanism using DES.
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