RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions

A critical step in malaria blood-stage infections is the invasion of red blood cells (RBCs) by merozoite forms of the Plasmodium parasite. Much progress has been made in defining the parasite ligands and host receptors that mediate this critical step. However, less well understood are the RBC biophysical determinants that influence parasite invasion. In this review we explore how Plasmodium falciparum merozoites interact with the RBC membrane during invasion to modulate RBC deformability and facilitate invasion. We further highlight RBC biomechanicsrelated polymorphisms that might have been selected for in human populations due to their ability to reduce parasite invasion. Such an understanding will reveal the translational potential of targeting host pathways affecting RBC biomechanical properties for the treatment of malaria.

Automated summary

This review explores the critical step of merozoite invasion of red blood cells in malaria infections and highlights the influence of red blood cell biophysical determinants on parasite invasion, as well as the polymorphisms of these determinants in human populations. Such understanding contributes to the development of malaria treatment strategies targeting host pathways affecting red blood cell biomechanical properties.