期刊
TRENDS IN NEUROSCIENCES
卷 45, 期 2, 页码 120-132出版社
CELL PRESS
DOI: 10.1016/j.tins.2021.11.005
关键词
-
This article reviews studies on the effects of stress on hippocampal spatial coding. The findings suggest that chronic stress disrupts the accuracy and specificity of CA1 spatial coding and alters hippocampal oscillations, while acute stress may have a facilitatory impact on spatial representations.
Hippocampal function is severely compromised by prolonged, uncontrollable stress. However, how stress alters neural representations of our surroundings and events that occur within them remains less clear. We review hippocampal place cell studies that examine how spatial coding is affected by acute and chronic stress, as well as by stress accompanying fear conditioning. Emerging data suggest that chronic stress disrupts the acuity and specificity of CA1 spatial coding, both in familiar and novel contexts, and alters hippocampal oscillations. By contrast, acute stress may have a facilitatory impact on spatial representations. These findings encourage a fresh look at the documented stressinduced changes in hippocampal anatomy and in vitro excitability, and offer a new perspective on the links between stress and memory.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据