CB2 and toll-like receptors crosstalk in microglia

Microglia play a major role in certain neuropathological conditions. In a recent paper, Reusch et al. demonstrated how signaling path-ways downstream of cannabinoid type 2 (CB2) and toll-like receptors (TLRs) converge in these cells. The findings suggest that CB2 receptors play a permissive role in microglia activation mediated by TLRs.

Automated summary

The research demonstrates the permissive role of CB2 receptors in microglia activation mediated by TLRs. The findings suggest that signaling pathways downstream of both CB2 and TLRs converge in microglia cells.