期刊
TRENDS IN MICROBIOLOGY
卷 30, 期 7, 页码 693-704出版社
CELL PRESS
DOI: 10.1016/j.tim.2021.12.013
关键词
-
资金
- Deutsche Forschungsgemeinschaft (DFG) [SPP 2225, HU 532/20-1]
- DFG Collaborative Research Centre [(CRC)/Transregio (TRR) 124]
- DFG Cluster of Excellence 'Balance of the Microverse'
- European Union Horizon 2020 grant [847507]
- Marie Sklodowska-Curie grant [812969]
- Leibniz Association Campus InfectoOptics [SAS-2015-HKI-LWC]
- Marie Curie Actions (MSCA) [812969] Funding Source: Marie Curie Actions (MSCA)
This review explores the emergence and evolution of fungal pathogens in humans, discussing their success as pathogens and the factors that may have selected for virulence. The concepts of antivirulence and avirulence genes are introduced, providing new insights into the pathogenicity of fungi that infect humans.
One billion people worldwide are affected by fungal pathogens, of which 1.6 million succumb to fungal infections per year. This review discusses the emergence and evolution of fungal pathogenesis in humans in the form of opportunistic commensal and environmental fungi. We explore the attributes that contribute to their success as pathogens and the scenarios which may have caused the evolutionary selection of virulence factors. This includes antivirulence and avirulence genes, notions that are new for fungal pathogens of humans but which are based on well established concepts in bacterial pathogens and phytopathogenic fungi. These ideas will ultimately help us to better understand the pathogenicity of fungi that infect humans: from the emergence to the finer adjustment of virulence to promote pathogen persistence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据