期刊
TRENDS IN IMMUNOLOGY
卷 42, 期 11, 页码 1009-1023出版社
CELL PRESS
DOI: 10.1016/j.it.2021.09.003
关键词
-
类别
资金
- National Institutes of Health (NIH) [T32 GM007067]
- NIH [R01 AI127552, R01 AI139314, R01 AI141478]
- Pew Biomedical Scholars Program of the Pew Charitable Trusts
- Mathers Foundation
- Burroughs Wellcome Fund
Interferons play specific roles in limiting local and systemic infection, showing synergistic activities and a spectrum of protective and detrimental effects during the infection response.
Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as key locations for host exposure to pathogens. Inhibition of viral establishment and spread at and from these mucosal sites is paramount for preventing severe disease, while concomitantly limiting putative detrimental effects of inflammation. Here, we compare the roles of type I, II, and III IFNs in regulating three archetypal viruses - norovirus, herpes simplex virus, and severe acute respiratory virus coronavirus 2 (SARS-CoV-2) - which infect distinct mammalian mucosal tissues. Emerging paradigms include highly specific roles for IFNs in limiting local versus systemic infection, synergistic activities, and a spectrum of protective versus detrimental effects of IFNs during the infection response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据