4.6 Review

The menace of obesity to depression and anxiety prevalence

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response

Bashkim Kadriu et al.

Summary: This study explored the impact of ketamine on the endogenous KYN pathway in individuals with bipolar depression and its relationship with depression-related behavioral and peripheral inflammatory markers. Results showed that post-ketamine IDO levels were significantly lower, while KYN and KynA levels were significantly increased. Inflammatory markers and behavioral measures predicted changes in the KYN pathway post ketamine treatment.

MOLECULAR PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group

Nils Opel et al.

Summary: The study revealed a significant association between obesity and cortical and subcortical abnormalities in the brain, showing similarities with patterns observed in neuropsychiatric disorders. The findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions.

MOLECULAR PSYCHIATRY (2021)

Review Endocrinology & Metabolism

Role of Macrophages in the Endocrine System

Abdul Rehman et al.

Summary: Macrophages play diverse roles in the endocrine system, interacting closely with endocrine cells to influence the development and function of endocrine glands. Gene expression profiling has identified various subpopulations of tissue macrophages within endocrine organs, providing important insights into disease pathogenesis and potential treatments. The molecular basis for crosstalk between macrophages and endocrine cells is being unraveled, offering multiple points for pharmacological intervention.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

Review Endocrinology & Metabolism

The impact of insulin on the serotonergic system and consequences on diabetes-associated mood disorders

Hugo Martin et al.

Summary: The review synthesizes the main mechanistic hypotheses explaining the comorbidity between diabetes and depression, as well as the impact of insulin on brain serotonergic neurones. Insulin inhibits serotonin levels, which may lead to symptoms of depression and anxiety. The study also suggests that antidiabetic drugs may have antidepressant-like effects.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

Review Behavioral Sciences

Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease

Simon Spichak et al.

Summary: The microbiome plays a crucial role in modulating the brain and behavior, with metabolites such as short-chain fatty acids, tryptophan, and bile acid being key for gut-brain communication. Studies on the human microbiota-gut-brain axis revealed disease-related alterations in microbial metabolic pathways in conditions like Alzheimer’s Disease, schizophrenia, anxiety, and depression. Further research is needed to confirm these findings and improve reproducibility and consistency in human microbiome analysis.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Immunology

Anxiety-like behavior in female mice is modulated by STAT3 signaling in midbrain dopamine neurons

Maria F. Fernandes et al.

Summary: The activation of STAT3 in midbrain dopamine neurons plays a key role in mediating the behavioral responses to the adiposity hormone leptin in male mice, while in female mice, the STAT3 signaling in mesolimbic dopamine neurons significantly affects feeding, anxiety-like behavior, and neuroendocrine responses.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Immunology

High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats

Melinda Hersey et al.

Summary: This study examined inflammatory markers and serotonergic dynamics in co-morbid obesity and depression, finding that a high-fat diet led to obesity and depressive-like symptoms in rats, marked by increased pro-inflammatory cytokines in the hippocampus. Additionally, impaired response to escitalopram in the hippocampus of obese rats was linked to elevated neuroinflammation and increased serotonin transporter expression.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Endocrinology & Metabolism

Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis

Bing-Yan Zeng et al.

Summary: This study evaluated the efficacy of different NIBS modalities for weight reduction in participants with obesity through NMA. The results showed that high-frequency repetitive TMS and high-frequency deep TMS had positive effects on reducing weight, providing a signal for the design of more robust and larger RCTs in the future.

INTERNATIONAL JOURNAL OF OBESITY (2021)

Review Endocrinology & Metabolism

Endocrine Factors in Key Structural and Intracellular Changes in Depression

Philip W. Gold

Summary: Endocrine disturbances play a key role in the pathophysiology of depression, affecting various neural sites and functions. Depression is associated with premature systemic diseases and a decreased response rate to current antidepressants, highlighting the need for new drug targets focusing on endocrine-mediated mechanisms.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

Review Endocrinology & Metabolism

Of 'junk food' and 'brain food': how parental diet influences offspring neurobiology and behaviour

Carina Bodden et al.

Summary: Unhealthy lifestyles and mental health problems are increasingly prevalent globally, with diet playing a significant role in influencing offspring brain development and behavior, potentially predisposing children to mental health issues. Evidence suggests that parental diet can program infant metabolism and neurobehavioral function, with implications for mental health and resilience. Additionally, the microbiota-gut-brain axis has been identified as a key mediator of host physiology, highlighting the impact of parental lineage on offspring gut health and neurobiology.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

Review Medicine, General & Internal

Brain Glucose Metabolism in Health, Obesity, and Cognitive Decline-Does Insulin Have Anything to Do with It? A Narrative Review

Eleni Rebelos et al.

Summary: Using [F-18]-FDG-PET to image brain glucose metabolism has been a valuable tool in diagnosing cognitive disorders like Alzheimer's disease, with recent studies revealing connections between obesity, diabetes, and alterations in brain glucose metabolism. Understanding whether changes in brain glucose metabolism are a key determinant in the pathophysiology of metabolic and neurologic disorders is crucial for advancing research in this field.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Nutrition & Dietetics

Association Between Dietary Inflammatory Index and Mental Health: A Systematic Review and Dose-Response Meta-Analysis

Guo-Qiang Chen et al.

Summary: The meta-analysis showed a strong association between a higher Dietary Inflammatory Index (DII) score and various mental health outcomes, such as symptoms of depression, anxiety, distress, and schizophrenia. Furthermore, there was a linear dose-response relationship between DII and symptoms of depression. This suggests that a pro-inflammatory diet may be a risk factor for mental disorders, highlighting the importance of novel nutritional psychiatry approaches for promoting good mental health.

FRONTIERS IN NUTRITION (2021)

Review Biochemistry & Molecular Biology

Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity

Ismael Gonzalez-Garcia et al.

Summary: Astrocytes are functionally integrated into neuronal regulatory circuits for metabolic control, particularly in the hypothalamus, where early cellular rearrangements may play a key role in the pathogenesis of obesity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Clinical Neurology

Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review

Emma Kopra et al.

Summary: Ketamine appears to induce anti-inflammatory effects in at least a proportion of depressed patients, with strong support from rodent studies. Clinical evidence is less robust, but most experiments also demonstrated decreases in peripheral inflammation. Further research is recommended to investigate markers in the central nervous system and examine the clinical relevance of inflammatory changes.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

Review Neurosciences

Sex differences in anxiety and depression: circuits and mechanisms

Debra A. Bangasser et al.

Summary: Male-dominated preclinical studies on anxiety and depression are being addressed to include females, leading to the discovery of new mechanisms and treatment targets. Epidemiological sex differences in these disorders are well-known, but the underlying circuits and mechanisms contributing to these differences still lack attention due to historical exclusion of females in research. Comparing the sexes may help in the discovery of novel therapeutics.

NATURE REVIEWS NEUROSCIENCE (2021)

Review Behavioral Sciences

Unravelling the impacts of western-style diets on brain, gut microbiota and cognition

Michael D. Kendig et al.

Summary: The rise in obesity prevalence is linked to modern environments that encourage high-fat, high-sugar diets, which have negative effects on cognitive function. Research suggests that obesity and diet impact cognition through multiple mechanisms across the human lifespan.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Multidisciplinary Sciences

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice

Akira Mizoguchi et al.

Summary: This study investigated the role of glucocorticoid receptor signaling in the reward system on the rewarding value of a high-fat diet under restricted caloric stress. Results showed that mice lacking functional GRs in dopaminergic neurons did not exhibit a preference for HFD, in contrast to corticostriatal neuron knockout mice and wild-type mice.

SCIENTIFIC REPORTS (2021)

Article Neurosciences

Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging

Amjad Samara et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2020)

Review Endocrinology & Metabolism

Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression

Thomas T. van Sloten et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

Review Clinical Neurology

Gut microbiota and major depressive disorder: A systematic review and meta-analysis

Kenji Sanada et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

Article Multidisciplinary Sciences

Nucleus accumbens cytoarchitecture predicts weight gain in children

Kristina M. Rapuano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biochemistry & Molecular Biology

Depression and obesity: evidence of shared biological mechanisms

Yuri Milaneschi et al.

MOLECULAR PSYCHIATRY (2019)

Article Multidisciplinary Sciences

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

Marion Soto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

T cell-mediated regulation of the microbiota protects against obesity

Charisse Petersen et al.

SCIENCE (2019)

Article Cell Biology

Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding

Jung Dae Kim et al.

CELL METABOLISM (2019)

Review Psychology, Biological

Effects of adiposity and metabolic dysfunction on cognition: A review

Michael C. Farruggia et al.

PHYSIOLOGY & BEHAVIOR (2019)

Article Neurosciences

Transcriptomic predictors of inflammation-induced depressed mood

Joshua Hyong-Jin Cho et al.

NEUROPSYCHOPHARMACOLOGY (2019)

Article Endocrinology & Metabolism

Hypothalamic microglia as potential regulators of metabolic physiology

Martin Valdearcos et al.

NATURE METABOLISM (2019)

Review Clinical Neurology

Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review

Mario F. Juruena et al.

JOURNAL OF AFFECTIVE DISORDERS (2018)

Article Medicine, Research & Experimental

Insulin regulates astrocyte gliotransmission and modulates behavior

Weikang Cai et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

Marion Soto et al.

MOLECULAR PSYCHIATRY (2018)

Article Neurosciences

Gut microbiome and depression: what we know and what we need to know

Gal Winter et al.

REVIEWS IN THE NEUROSCIENCES (2018)

Article Medicine, General & Internal

Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study

Rafael Gafoor et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Article Medicine, General & Internal

Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study

Rafael Gafoor et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Article Biochemistry & Molecular Biology

Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation

Miriam Gutierrez-Martos et al.

ADDICTION BIOLOGY (2018)

Review Neurosciences

Preclinical Sex Differences in Depression and Antidepressant Response: Implications for Clinical Research

Nikolaos Kokras et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Article Biochemistry & Molecular Biology

Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency

M. A. Labouesse et al.

MOLECULAR PSYCHIATRY (2017)

Review Neurosciences

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

Vasiliki Michopoulos et al.

NEUROPSYCHOPHARMACOLOGY (2017)

Review Medicine, Research & Experimental

Hypothalamic inflammation in obesity and metabolic disease

Alexander Jais et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Biochemistry & Molecular Biology

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis

Huanqing Gao et al.

LIPIDS IN HEALTH AND DISEASE (2017)

Article Neurosciences

Social stress induces neurovascular pathology promoting depression

Caroline Menard et al.

NATURE NEUROSCIENCE (2017)

Editorial Material Endocrinology & Metabolism

Obesity and Cortisol: New Perspectives on an Old Theme

Elisabeth F. C. van Rossum

OBESITY (2017)

Article Endocrinology & Metabolism

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

J. D. Douglass et al.

MOLECULAR METABOLISM (2017)

Article Endocrinology & Metabolism

Dietary sugars, not lipids, drive hypothalamic inflammation

Yuanqing Gao et al.

MOLECULAR METABOLISM (2017)

Article Multidisciplinary Sciences

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

Daniela Rebolledo-Solleiro et al.

PLOS ONE (2017)

Article Multidisciplinary Sciences

Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior

Seungrie Han et al.

SCIENTIFIC REPORTS (2017)

Article Immunology

Leptin resistance elicits depressive-like behaviors in rats

V. A. Macht et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

Article Pharmacology & Pharmacy

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice

Juliane Zemdegs et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Neurosciences

High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation

Sophie Dutheil et al.

NEUROPSYCHOPHARMACOLOGY (2016)

Review Immunology

Chronic peripheral inflammation, hippocampal neurogenesis, and behavior

Vera Chesnokova et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

Article Clinical Neurology

Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice

Stephanie Auguste et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2016)

Article Medicine, Research & Experimental

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

Giuseppe Faraco et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Pharmacology & Pharmacy

Antidepressant therapies inhibit inflammation and microglial M1-polarization

Hans O. Kalkman et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Review Behavioral Sciences

Dopamine signalling adaptations by prolonged high-fat feeding

Lea Decarie-Spain et al.

CURRENT OPINION IN BEHAVIORAL SCIENCES (2016)

Article Neurosciences

Obese-type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity

Annadora J. Bruce-Keller et al.

BIOLOGICAL PSYCHIATRY (2015)

Article Immunology

Astrocytic TNFα regulates the behavioral response to antidepressants

Rachna Duseja et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

Article Psychology, Biological

Predictive behaviors for anxiety and depression in female Wistar rats subjected to cafeteria diet and stress

Dieferson da Costa Estrela et al.

PHYSIOLOGY & BEHAVIOR (2015)

Article Multidisciplinary Sciences

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Christine M. Sandiego et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function

Miriam E. Bocarsly et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

Andre Kleinridders et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Endocrinology & Metabolism

Depressive symptoms, anxiety and well-being among metabolic health obese subtypes

Catherine M. Phillips et al.

PSYCHONEUROENDOCRINOLOGY (2015)

Review Neurosciences

Depression as a Microglial Disease

Raz Yirmiya et al.

TRENDS IN NEUROSCIENCES (2015)

Article Neurosciences

Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity

Joanna R. Erion et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies

M. Jokela et al.

MOLECULAR PSYCHIATRY (2014)

Article Biochemistry & Molecular Biology

Role of brain transmigrating neutrophils in depression-like behavior during systemic infection

A. Aguliar-Valles et al.

MOLECULAR PSYCHIATRY (2014)

Review Endocrinology & Metabolism

Endothelium as a gatekeeper of fatty acid transport

Devi Mehrotra et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

Article Nutrition & Dietetics

Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study

F. Soriguer et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2013)

Article Clinical Neurology

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

Ming Guo et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)

Article Endocrinology & Metabolism

Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal

S. Sharma et al.

INTERNATIONAL JOURNAL OF OBESITY (2013)

Review Clinical Neurology

Epidemiology of depression and diabetes: A systematic review

Tapash Roy et al.

JOURNAL OF AFFECTIVE DISORDERS (2012)

Article Medicine, General & Internal

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

David J. Kupfer et al.

LANCET (2012)

Article Psychiatry

Role of cytokines in atypical depression

Ho-Kyoung Yoon et al.

NORDIC JOURNAL OF PSYCHIATRY (2012)

Article Multidisciplinary Sciences

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

Sheldon Cohen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Endocrinology & Metabolism

Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity

Nobuko Yamada et al.

ENDOCRINOLOGY (2011)

Review Endocrinology & Metabolism

The relationship between abdominal obesity and depression in the general population: A systematic review and meta-analysis

Qunyan Xu et al.

OBESITY RESEARCH & CLINICAL PRACTICE (2011)

Review Psychiatry

Overweight, Obesity, and Depression A Systematic Review and Meta-analysis of Longitudinal Studies

Floriana S. Luppino et al.

ARCHIVES OF GENERAL PSYCHIATRY (2010)

Review Endocrinology & Metabolism

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Joshua P. Thaler et al.

ENDOCRINOLOGY (2010)

Article Biochemistry & Molecular Biology

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation

C. Rummel et al.

MOLECULAR PSYCHIATRY (2010)

Review Endocrinology & Metabolism

Stress-induced obesity and the emotional nervous system

Mary F. Dallman

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)

Article Endocrinology & Metabolism

Depression and anxiety among US adults: associations with body mass index

G. Zhao et al.

INTERNATIONAL JOURNAL OF OBESITY (2009)

Article Medicine, Research & Experimental

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

Stephen C. Benoit et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Biochemistry & Molecular Biology

Induction of leptin resistance through direct interaction of C-reactive protein with leptin

K Chen et al.

NATURE MEDICINE (2006)

Article Multidisciplinary Sciences

Leptin: A potential novel antidepressant

XY Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Psychiatry

Treatment of depression with atypical features:: A meta-analytic approach

V Henkel et al.

PSYCHIATRY RESEARCH (2006)

Article Endocrinology & Metabolism

Leptin treatment ameliorates anxiety in ob/ob obese mice

A Asakawa et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2003)

Article Immunology

Treatment of cytokine-induced depression

L Capuron et al.

BRAIN BEHAVIOR AND IMMUNITY (2002)