4.6 Review

Alpha-Ketoglutarate dietary supplementation to improve health in humans

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Summary: AKG, an intermediate of the tricarboxylic acid cycle, plays diverse roles in cellular metabolism and regulation, with potential anti-aging effects demonstrated in experimental models. Its geroprotective actions may involve epigenetic regulation, antioxidant properties, and mimicking caloric restriction and hormesis. AKG's influence on mitochondrial respiration and induction of ROS production could lead to beneficial biological effects according to hormesis hypothesis, despite discrepancies in different models and limitations as a geroprotective drug.

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