相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test
Oleksandr Demidenko et al.
Aging-US (2021)
Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent
Maria M. Bayliak et al.
AGEING RESEARCH REVIEWS (2021)
Impact of using the updated EWGSOP2 definition in diagnosing sarcopenia: A clinical perspective
Jeanine M. Van Ancum et al.
ARCHIVES OF GERONTOLOGY AND GERIATRICS (2020)
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
Azar Asadi Shahmirzadi et al.
CELL METABOLISM (2020)
Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
Yuan Wang et al.
NATURE COMMUNICATIONS (2020)
Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis
Suey S. Y. Yeung et al.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)
Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
Yuan Su et al.
AGING-US (2019)
Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways
Aleksandra Zurek et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
α-Ketoglutarate links p53 to cell fate during tumour suppression
John P. Morris et al.
NATURE (2019)
α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development
Xiongjun Wang et al.
MOLECULAR CELL (2019)
alpha-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway
Xingcai Cai et al.
FASEB JOURNAL (2018)
Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use
Barbara Zdzisinska et al.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2017)
Alpha-ketoglutarate (AKG) lowers body weight and affects intestinal innate immunity through influencing intestinal microbiota
Shuai Chen et al.
ONCOTARGET (2017)
Administration of alpha-ketoglutarate improves epithelial restitution under stress injury in early-weaning piglets
Liuqin He et al.
ONCOTARGET (2017)
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Pu-Ste Liu et al.
NATURE IMMUNOLOGY (2017)
The DrugAge database of aging-related drugs
Diogo Barardo et al.
AGING CELL (2017)
The protective and therapeutic effect of exclusive and combined treatment with alpha-ketoglutarate sodium salt and ipriflavone on bone loss in orchidectomized rats
R. P. Radzki et al.
JOURNAL OF NUTRITION HEALTH & AGING (2016)
Oxygen sensing in intestinal mucosal inflammation
Katharina Fluck et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2016)
Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells
Qian Jiang et al.
AMINO ACIDS (2016)
Alpha-Ketoglutarate: Physiological Functions and Applications
Nan Wu et al.
BIOMOLECULES & THERAPEUTICS (2016)
Dietary alpha-ketoglutarate increases cold tolerance in Drosophila melanogaster and enhances protein pool and antioxidant defense in sex-specific manner
Maria M. Bayliak et al.
JOURNAL OF THERMAL BIOLOGY (2016)
Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
Loubna Abdel Hadi et al.
MEDIATORS OF INFLAMMATION (2016)
Targeting Oxidative Stress in Central Nervous System Disorders
Manisha Patel
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Increased Circulating Levels of Alpha-Ketoglutarate in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease
Gemma Aragones et al.
PLOS ONE (2016)
Dietary supplementation with glutamate precursor α-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs
Lei Wang et al.
AMINO ACIDS (2015)
The Physiological Basis and Nutritional Function of Alpha-ketoglutarate
Liuqin He et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2015)
Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis
Julijana Ivanisevic et al.
SCIENTIFIC REPORTS (2015)
The Role of Oxidative Stress in Neurodegenerative Diseases
Geon Ha Kim et al.
EXPERIMENTAL NEUROBIOLOGY (2015)
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Bryce W. Carey et al.
NATURE (2015)
Geroscience: Linking Aging to Chronic Disease
Brian K. Kennedy et al.
CELL (2014)
Caloric restriction and the aging process: a critique
Rajindar S. Sohal et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Randall M. Chin et al.
NATURE (2014)
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-therapeutic perspectives
Milan Holecek
METABOLIC BRAIN DISEASE (2014)
Preparation and evaluation of sustained-release azithromycin tablets in vitro and in vivo
Le Sun et al.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism
Natsuko Tokonami et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
JOURNAL OF CLINICAL INVESTIGATION (2013)
Naive pluripotency is associated with global DNA hypomethylation
Harry G. Leitch et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells
Kang Yao et al.
AMINO ACIDS (2012)
Anti-osteopenic effect of alpha-ketoglutarate sodium salt in ovariectomized rats
Radoslaw Piotr Radzki et al.
JOURNAL OF BONE AND MINERAL METABOLISM (2012)
Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men
Benjamin Wax et al.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION (2012)
Metabolic Pathways and Activity-Dependent Modulation of Glutamate Concentration in the Human Brain
Silvia Mangia et al.
NEUROCHEMICAL RESEARCH (2012)
Revisiting the TCA cycle: signaling to tumor formation
Nuno Raimundo et al.
TRENDS IN MOLECULAR MEDICINE (2011)
Dietary α-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets
Yongqing Hou et al.
AMINO ACIDS (2010)
Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model
Ken Matsumoto et al.
CANCER SCIENCE (2009)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
NATURE (2009)
Identifying the direct effects of ammonia on the brain
Cristina R. Bosoi et al.
METABOLIC BRAIN DISEASE (2009)
Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
D. A. Tennant et al.
ONCOGENE (2009)
Effect of dietary alpha-ketoglutarate on blood lipid profile during hypercholesterolaemia in rats
Radoslaw P. Radzki et al.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2009)
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman et al.
SCIENCE (2009)
The absorption, tissue distribution and excretion of enteraly administered α-ketoglutarate in rats
R. Filip et al.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION (2008)
Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice
Eui Dong Son et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)
Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
Elaine D. MacKenzie et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: Six-month study
Rafal S. Filip et al.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (2007)
Conservation of the metabolomic response to starvation across two divergent microbes
Matthew J. Brauer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1α and inhibits angiogenesis
Ken Matsumoto et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Intraduodenal infusion of α-ketoglutarate decreases whole body energy expenditure in growing pigs
Peter Junghans et al.
CLINICAL NUTRITION (2006)
Signalling hypoxia by HIF hydroxylases
CJ Schofield et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
α-ketoglutarate (AKG) absorption from pig intestine and plasma pharmacokinetics
M Dabek et al.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION (2005)
Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations
PJ Pollard et al.
HUMAN MOLECULAR GENETICS (2005)
L-ornithine α-ketoglutarate in HIV infection:: Effects on muscle, gastrointestinal, and immune functions
VL Karsegard et al.
NUTRITION (2004)
Use of ornithine alpha-ketoglutarate in clinical nutrition of elderly patients
F Blonde-Cynober et al.
NUTRITION (2003)
α-ketoglutarate-supplemented enteral nutrition.: Effects on postoperative nitrogen balance and muscle catabolism
M Wirén et al.
NUTRITION (2002)
Nutrient absorption and intestinal adaptation with ageing
T Woudstra et al.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2002)
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
D Astuti et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Physiology of nitric oxide in skeletal muscle
JS Stamler et al.
PHYSIOLOGICAL REVIEWS (2001)
Ornithine α-ketoglutarate improves wound healing in severe burn patients:: A prospective randomized double-blind trial versus isonitrogenous controls
C Coudray-Lucas et al.
CRITICAL CARE MEDICINE (2000)
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
BE Baysal et al.
SCIENCE (2000)