期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 32, 期 12, 页码 980-993出版社
CELL PRESS
DOI: 10.1016/j.tem.2021.09.006
关键词
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资金
- National Institutes of Health (NIH) [R01 AG066653]
- St Baldrick's Career Development Award
- V-Scholar Grant
- Rally Foundation Independent Investigator Grant
- NIH/NCI training grant [T32CA165990]
- [R35 NS116824]
- [P01 NS097197]
N-linked glycosylation is a complex process that connects metabolism to signaling in almost all cells, playing important roles in the brain. Aberrant N-linked glycosylation may potentially drive neurological disorders.
N-linked glycosylation is a complex, co-and post-translational series of events that connects metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans multiple cellular compartments, and early N-linked glycan biosynthesis is a central mediator of protein folding and the unfolded protein response (UPR). In the brain, N-linked glycosylated proteins participate in a myriad of processes, from electrical gradients to neurotransmission. However, it is less clear how perturbations in N-linked glycosylation impact and even potentially drive aspects of neurological disorders. In this review, we discuss our current understanding of the metabolic origins of N-linked glycans in the brain, their role in modulating neuronal function, and how aberrant N-linked glycosylation can drive neurological disorders.
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