Cep55: abscission boss or assistant?

Abscission is the second stage of cytokinesis. Cep55, a coiled-coil protein, is thought to recruit endosomal sorting complexes required for transport (ESCRTs) to the midbody to complete abscission. However, recent studies of Cep55-knockout mice reveal that most cells can complete abscission without Cep55. More work is needed to understand abscission mechanisms in different cell types.

Automated summary

Abscission, the second stage of cytokinesis, is thought to be completed by the recruitment of ESCRTs by the coiled-coil protein Cep55. Recent studies with Cep55-knockout mice show that most cells can still complete abscission without Cep55, indicating the need for further research on abscission mechanisms in different cell types.