期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 46, 期 10, 页码 832-847出版社
CELL PRESS
DOI: 10.1016/j.tibs.2021.05.007
关键词
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资金
- National Institutes of Health NIGMS [GM114141]
- Edward Mallinckrodt Foundation
- National Science Foundation Graduate Research Fellowship [NSF-GRFP DGE-1656466]
- NIH NIGMS [T32GM007388]
Nuclear lamins are ancient type V intermediate filaments with diverse functions that are regulated by a range of post-translational modifications, playing crucial roles in maintaining nuclear shape, mechanosignaling, chromatin stability, gene expression, and cell cycle progression.
Nuclear lamins are ancient type V intermediate filaments with diverse functions that include maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin, regulating gene expression, and contributing to cell cycle progression. Despite these numerous roles, an outstanding question has been how lamins are regulated. Accumulating work indicates that a range of lamin post-translational modifications (PTMs) control their functions both in homeostatic cells and in disease states such as progeria, muscular dystrophy, and viral infection. Here, we review the current knowledge of the diverse types of PTMs that regulate lamins in a site-specific manner. We highlight methods that can be used to characterize lamin PTMs whose functions are currently unknown and provide a perspective on the future of the lamin PTM field.
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