期刊
TRANSPLANT INTERNATIONAL
卷 34, 期 12, 页码 2494-2506出版社
FRONTIERS MEDIA SA
DOI: 10.1111/tri.14131
关键词
epidemiology; kidney transplantation; survival analysis
资金
- Spanish competitive grant from the Instituto de Salud Carlos III [PI19/01710]
- FEDER
- Instituto de Salud Carlos III [INT19/00051]
- Spanish Ministry of Health ISCIII FIS-FEDER [PI16/00619]
- ISCIII FEDER RedinRen [RD16/0009/0013]
This study analyzed 1161 consecutive kidney transplantations and found that using highly expanded criteria donors (ECD) and recipients for controlled circulatory death kidney transplantation (cDCD-KT) resulted in the lowest graft survival rates. Recipient age, gender, dialysis vintage, previous cardiovascular events, and receiving cDCD were predictors of patient death.
Outcomes of kidney transplantation (KT) after controlled circulatory death (cDCD) with highly expanded criteria donors (ECD) and recipients have not been thoroughly evaluated. We analyzed in a multicenter cohort of 1161 consecutive KT, granular baseline donor and recipient factors predicting transplant outcomes, selected by bootstrapping and Cox proportional hazards, and were validated in a contemporaneous European KT cohort (n = 1585). 74.3% were DBD and 25.7% cDCD-KT. ECD-KT showed the poorest graft survival rates, irrespective of cDCD or DBD (log-rank < 0.001). Besides standard ECD classification, dialysis vintage, older age, and previous cardiovascular recipient events together with low class-II-HLA match, long cold ischemia time and combining a diabetic donor with a cDCD predicted graft loss (C-Index 0.715, 95% CI 0.675-0.755). External validation showed good prediction accuracy (C-Index 0.697, 95%CI 0.643-0.741). Recipient older age, male gender, dialysis vintage, previous cardiovascular events, and receiving a cDCD independently predicted patient death. Benefit/risk assessment of undergoing KT was compared with concurrent waitlisted candidates, and despite the fact that undergoing KT outperformed remaining waitlisted, remarkably high mortality rates were predicted if KT was undertaken under the worst risk-prediction model. Strategies to increase the donor pool, including cDCD transplants with highly expanded donor and recipient candidates, should be performed with caution.
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