期刊
TRANSLATIONAL ONCOLOGY
卷 15, 期 1, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2021.101257
关键词
Monoclonal antibody; Annexin A2; Cancer stem cells; Progenitors; Epigenetic potentiation; Active cooperative cell migration
类别
资金
- NCCS, Pune
- Department of Biotechnology, Government of India, New Delhi [BT/PR7186/MED/14/965/2006]
- Department of Biotechnology, New Delhi, India
- Council of Scientific and Industrial Research, New Delhi, India
- University Grants Commission, New Delhi India
The monoclonal antibody mAb150 targets cancer stem cells, promoting their reentry into the cell cycle and disrupting tumor dormancy, leading to effective tumor targeting.
The involvement of cancer stem cells (CSCs) in driving tumor dormancy and drug resistance is well established. Most therapeutic regimens however are ineffective in targeting these regenerative populations. We report the development and evaluation of a monoclonal antibody, mAb150, which targets the metastasis associated antigen, Annexin A2 (AnxA2) through recognition of a N-terminal epitope. Treatment with mAb150 potentiated reentry of CSCs into the cell cycle that perturbed tumor dormancy and facilitated targeting of CSCs as was validated by in vitro and in vivo assays. Epigenetic potentiation further improved mAb150 efficacy in achieving total tumor regression by targeting regenerative populations to achieve tumor regression, specifically in high-grade serous ovarian adenocarcinoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据