Sensor-based MIP technologies for targeted metabolomics analysis

In recent years, metabolomics, identification and profiling of metabolites, have gained broad interest compared to other omics technologies and are progressively being utilized for biomarker discoveries. Therefore, the application of metabolomics in different fields are increasing day by day because of its high throughput results. However, the application of metabolomics requires state-of-the-art analytical approaches for the analysis. The complexity and limited availability of these instruments are restricting parameters for applying metabolomics studies in routine analysis. This problem may be overcome with molecularly imprinted polymer (MIP)-based electro sensors since they have high selectivity, sensitivity, easy applicability, portability, and low cost. This is the final step before developing end point-of-care tests (POCT), which patients can easily apply. MIP sensors will have more applications in the targeted metabolomics analysis to develop POCT systems. This review analyzes various metabolites using MIP-based electrochemical methods for their potential usage as POCT and biomarker research based on targeted metabolomics analysis requirements. The future applications for the sensitive assay of metabolites in medicine and clinical trials are also discussed. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Metabolomics, as a technology for identifying and analyzing metabolites, has gained broad interest and is widely used for biomarker discoveries due to its high throughput results. However, the application of metabolomics requires advanced analytical methods. The use of molecularly imprinted polymer (MIP)-based electro sensors, which have high selectivity, sensitivity, easy applicability, portability, and low cost, can overcome the limitations of complex and limited availability of instruments. These sensors have great potential in targeted metabolomics analysis and the development of point-of-care tests (POCT) for easy patient application.