Advances in the enzymatic biofuel cell powered sensing systems for tumor diagnosis and regulation

Tumors are the leading killers of human health, however, diagnosis on tumors are neither timely nor accurate due to the high detection cost and high technical requirements. For cancer diagnosis and treatment, self-powered biosensors based on enzymatic biofuel cells have the advantages of simple structure, easy miniaturization, instantaneous response to analytes, and high economic applicability. It is of great significance for the development of portable and personalized biosensors. Over the past twenty years, a number of prominent self-powered biosensors have been created to diagnose tumor via analyzing the corresponding biomarkers with low cost. What's more, some intelligent self-powered biosensors with integrated diagnostic and therapeutic functions have also been reported. In this review, the focus of this work is on the development of self-powered biosensors in tumor diagnosis and intelligent regulation from the aspects of design and working principles. Furthermore, the challenge for the future work is also analyzed. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Tumors are a major threat to human health, and the timely and accurate diagnosis of tumors is still a challenge. Self-powered biosensors based on enzymatic biofuel cells offer a promising solution with their simple structure, easy miniaturization, quick response to analytes, and economic feasibility. These biosensors have great significance for the development of portable and personalized diagnostic tools. This review focuses on the design and working principles of self-powered biosensors in tumor diagnosis and intelligent regulation, and discusses the future challenges.