On-line supercritical fluid extraction-supercritical fluid chromatography (SFE-SFC) at a glance: A coupling story

The development of automatized hyphenated systems is attractive to avoid sampling error, save time and reduce costs. Among these systems, on-line SFE-SFC allows the extraction, the separation, and the detection of molecules in an efficient, quick and eco-friendly way. After a historical introduction and explanation on the use of supercritical fluids for extraction or analysis, principles of supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) will be presented. Partially-supercritical on-line systems (e.g. SFE-liquid chromatography) will be compared before discussing about the evolution of on-line SFE-SFC over the past decades. Given the significance of the hyphenation between SFE and SFC to achieve a successful transfer, different devices will be examined to gain a better understanding of the coupling challenges and to determine the most advantageous configuration. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

The development of automatized hyphenated systems is attractive for avoiding sampling error, saving time, and reducing costs. Among these systems, on-line SFE-SFC allows efficient, quick, and eco-friendly extraction, separation, and detection of molecules. The principles of supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) are discussed, along with comparisons of partially-supercritical on-line systems before examining the evolution of on-line SFE-SFC over the past decades. Different devices for better understanding coupling challenges and determining advantageous configurations are also examined.