期刊
TOXICOLOGY LETTERS
卷 353, 期 -, 页码 13-19出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2021.10.002
关键词
Lead; Blood lead levels; Iron; DMT1; SNP; Genotype
类别
资金
- Manipal Academy of Higher Education [131700103]
- Directorate of Minorities [DOM/FELLOW-SHIP/CR-84/2017-18]
- Dr. T.M.A Pai foundation
This study investigated the influence of DMT1 gene polymorphism on blood lead levels, showing that heterozygous CA carriers had higher Pb-B levels and a negative association with hemoglobin. The C allele may be a risk allele contributing to increased susceptibility to high Pb-B retention in lead exposed individuals.
Lead (Pb) is an environmental and public health toxicant. It affects various organ systems of the body, thereby disrupting their normal functions. To date, several genes that are known to influence the mechanism of action of lead and toxicity have been studied. Among them, the iron transporter gene, SLC11A2 (Solute Carrier 11 group A member 2) which codes for the transmembrane protein, DMT1 (Divalent Metal Transporter 1) has shown to transport other metals including zinc, copper, and lead. We investigated the influence of DMT1 polymorphism (rs224589) on blood lead (Pb-B) levels. In the present study, we enrolled 113 lead-exposed workers and performed a comprehensive biochemical analysis and genetic composition. The frequency of DMT1 variants observed in the total subjects (n = 113) was 42 % for homozygous CC wild type, 54 % for heterozygous CA, and 4 % for homozygous AA mutant. The heterozygous CA carriers presented higher Pb-B levels compared to wild type CC and mutant AA carriers. Further, a negative association was observed between Pb-B levels and hemoglobin in heterozygous CA carriers. Hence, C allele may be the risk allele that contributes to increased susceptibility to high Pb-B retention, and genotyping of DMT1 in lead exposed subjects might be used as a prognostic marker to impede organ damage due to lead toxicity. (c) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据