相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
Laurens F. M. Verscheijden et al.
PHARMACOLOGY & THERAPEUTICS (2020)
Physiologically based pharmacokinetic modeling: A promising tool for translational research and regulatory toxicology
Kiara Fairman et al.
CURRENT OPINION IN TOXICOLOGY (2020)
Quantitative in vitro-to-in vivo extrapolation (QIVIVE) of estrogenic and anti-androgenic potencies of BPA and BADGE analogues
Ans Punt et al.
ARCHIVES OF TOXICOLOGY (2019)
Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
Laurens F. M. Verscheijden et al.
PLOS COMPUTATIONAL BIOLOGY (2019)
Changes in neuronal activity in rat primary cortical cultures induced by illicit drugs and new psychoactive substances (NPS) following prolonged exposure and washout to mimic human exposure scenarios
Anne Zwartsen et al.
NEUROTOXICOLOGY (2019)
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach
Yumi Yamamoto et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)
Neurotoxicity screening of new psychoactive substances (NPS): Effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA)
Anne Zwartsen et al.
NEUROTOXICOLOGY (2018)
Human iPSC-derived neuronal models for in vitro neurotoxicity assessment
Anke M. Tukker et al.
NEUROTOXICOLOGY (2018)
Development of a human physiologically based pharmacokinetic (PBPK) model for phthalate (DEHP) and its metabolites: A bottom up modeling approach
Raju Prasad Sharma et al.
TOXICOLOGY LETTERS (2018)
Pharmacokinetic Studies of Baclofen Are Not Sufficient to Establish an Optimized Dosage for Management of Alcohol Disorder
Nicolas Simon et al.
FRONTIERS IN PSYCHIATRY (2018)
Neuropharmacological characterization of the new psychoactive substance methoxetamine
Laura Hondebrink et al.
NEUROPHARMACOLOGY (2017)
The great barrier belief: The blood–brain barrier and considerations for juvenile toxicity studies
Georg Schmitt et al.
REPRODUCTIVE TOXICOLOGY (2017)
Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples
Zhoumeng Lin et al.
TOXICOLOGICAL SCIENCES (2017)
Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes
Emma E. J. Kasteel et al.
TOXICOLOGY LETTERS (2017)
A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics
Natalie S. Schmitz et al.
PM&R (2017)
SLC and ABC Transporters: Expression, Localization, and Species Differences at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers
Marilyn E. Morris et al.
AAPS JOURNAL (2017)
A pharmacokinetic-pharmacodynamic model for intrathecal baclofen in patients with severe spasticity
H. W. Heetla et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)
Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro edata
Lu Gaohua et al.
DRUG METABOLISM AND PHARMACOKINETICS (2016)
Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings
L. Hondebrink et al.
NEUROTOXICOLOGY (2016)
A Pilot Study Assessing Pharmacokinetics and Tolerability of Oral and Intravenous Baclofen in Healthy Adult Volunteers
Suresh K. Agarwal et al.
JOURNAL OF CHILD NEUROLOGY (2015)
Off-Label Use of Drugs in Children
Daniel A. C. Frattarelli et al.
PEDIATRICS (2014)
A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
Romeo Cecchelli et al.
PLOS ONE (2014)
Quantitative Atlas of Blood-Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset
Yutaro Hoshi et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
Baclofen intoxication: a fun drug causing deep coma and nonconvulsive status epilepticus-a case report and review of the literature
Guido F. Weisshaar et al.
EUROPEAN JOURNAL OF PEDIATRICS (2012)
Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes
Elodie Vandenhaute et al.
CURRENT NEUROVASCULAR RESEARCH (2011)
Structure-Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids
Markus Friden et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps
George Loizou et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2008)
Estimating the approximation error when fixing unessential factors in global sensitivity analysis
I. M. Sobol et al.
RELIABILITY ENGINEERING & SYSTEM SAFETY (2007)
Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intratbecal infusion in pigs
Christopher M. Bernards
ANESTHESIOLOGY (2006)
Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions
Trudy Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate-to-strong bases
T Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Orally delivered baclofen to control spastic hypertonia in acquired brain injury
JM Meythaler et al.
JOURNAL OF HEAD TRAUMA REHABILITATION (2004)
Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux disease
HE Wiersma et al.
THERAPEUTIC DRUG MONITORING (2003)
分享论文
