期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 436, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2021.115861
关键词
NLRP3 inflammasome; Gasdermin; LPS; Pyroptosis; Curcumin; Dexamethasone
资金
- Technology development Program (TDP division)
- Science and Engineering Research Board (SERB)
- Department of Science and Technology, New Delhi, India
This study found that intranasal administration of curcumin can reduce asthma exacerbations caused by endotoxin by modulating NLRP3 activation, and it also has anti-inflammatory effects.
The inflammasome NOD-like receptor (NLR) family, the pyrin domain containing 3 (NLRP3) is closely associated with exacerbation of asthma as endotoxin (lipopolysaccharide, LPS) is one of its activators present in the environment. Present study is undertaken to investigate anti-inflammatory effects of a well known phyto-chemical, curcumin, which might regulate LPS exposed asthma exacerbations by modulating NLRP3 activation if given through intranasal route. Balb/c mice were sensitized with intraperitoneal injection of OVA (Ovalbumin; 100 mu g of OVA with alum) from day 1 to 8 and exposed to LPS with 1% OVA aerosol from day 9 to 15. LPS (0.1 mu g) was given an hour before sensitization and OVA-aerosol challenge. Significant decrease in inflammatory cell recruitment and restoration of structural changes in lungs, alterations in mRNA and protein expressions of TLR-4, NF-kappa B, NLRP3, Caspase-1, IL-1 beta, MMP-9, IL-5 and IL-17 in intranasal curcumin alone and corticosteroid com-bined pretreatment group.
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