期刊
TOXICOLOGY
卷 465, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2021.153049
关键词
protein misfolding; aggregation; pesticide; heavy metals; neurodegenerative disorder; protein aggregation disorder; proteotoxicity
资金
- Council of Scientific and Industrial Research, India
Physiological conditions and environmental risk factors play significant roles in influencing protein structure and disease development.
The adverse physiological conditions have been long known to impact protein synthesis, folding and functionality. Major physiological factors such as the effect of pH, temperature, salt and pressure are extensively studied for their impact on protein structure and homeostasis. However, in the current scenario, the environmental risk factors (pollutants) have gained impetus in research because of their increasing concentrations in the environment and strong epidemiologic link with protein aggregation disorders. Here, we review the physiological and environmental risk factors for their impact on protein conformational changes, misfolding, aggregation, and associated pathological conditions, especially environmental risk factors associated pathologies.
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