Fe3O4@Au-rGO Nanocomposite/Ionic Liquid Modified Sensor for Ultrasensitive and Selective Sensing of Doxorubicin

Herein, a novel electrochemical nanostructure sensor for ultrasensitive doxorubicin (DOX) determination was developed using a modified carbon paste electrode with Fe3O4@Au-reduced graphene oxide nanocomposite and n-butyl-3-methylimidazolium-hexafluorophosphate. The Fe3O4@Au-rGO was characterized by UV-Vis, XRD, TEM, FESEM, and VSM methods. The characteristic evaluation of nanocomposite showed that Fe3O4@Au nanoparticles were in a nanometric range and successfully immobilized onto the graphene oxide surface. The developed sensor was of a superior capability for monitoring of DOX thanks to the synergistic effects of Fe3O4@Au-reduced graphene oxide nanocomposite and ionic liquid. For DOX, the square wave voltammetry response had a linear dynamic range of 0.003-600.0 mu M and a detection limit of 1.7 nM. Finally, the monitoring of DOX in real human urine samples offered satisfactory results.

Automated summary

A novel electrochemical nanostructure sensor was developed for ultrasensitive determination of doxorubicin (DOX). The sensor utilized a modified carbon paste electrode with Fe3O4@Au-reduced graphene oxide nanocomposite and n-butyl-3-methylimidazolium-hexafluorophosphate. The sensor showed superior capability for monitoring DOX in real human urine samples.