期刊
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
卷 19, 期 2, 页码 205-219出版社
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
DOI: 10.1007/s13770-021-00403-7
关键词
Tumor microenvironment; Nanoparticles; Cancer treatments; Drug delivery; Biomaterials
资金
- National Research Foundation (NRF) of Korea - Ministry of Science and ICT (MSIT), Republic of Korea [2021R1A2C4001776, 2020H1D3A1A04105814, 2020M2D9A3094208]
- Korea Medical Device Development Fund grant - Korean government (MSIT)
- Ministry of Trade, Industry and Energy
- Ministry of Health & Welfare, Ministry of Food and Drug Safety [202012D21-02]
- Catholic University of Korea, Research Fund
- National Research Foundation of Korea [2020H1D3A1A04105814, 2021R1A2C4001776] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Cancer treatment faces challenges due to the resistance mechanism of cancer cells related to the tumor microenvironment. Utilizing functional nanoparticles to modulate the tumor microenvironment can effectively treat refractory cancer, potentially maximizing cancer treatment efficiency when combined with modern cancer therapeutics.
Cancer is one of the major diseases that threaten human life worldwide. Despite advances in cancer treatment techniques, such as radiation therapy, chemotherapy, targeted therapy, and immunotherapy, it is still difficult to cure cancer because of the resistance mechanism of cancer cells. Current understanding of tumor biology has revealed that resistance to these anticancer therapies is due to the tumor microenvironment (TME) represented by hypoxia, acidity, dense extracellular matrix, and immunosuppression. This review demonstrates the latest strategies for effective cancer treatment using functional nanoparticles that can modulate the TME. Indeed, preclinical studies have shown that functional nanoparticles can effectively modulate the TME to treat refractory cancer. This strategy of using TMEs with controllable functional nanoparticles is expected to maximize cancer treatment efficiency in the future by combining it with various modern cancer therapeutics.
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