Aspirin impacts on stem cells: Implications for therapeutic targets

Despite the regenerative potential of stem cell therapy in pre-clinical investigations, clinical translation of cellbased therapy has not been completely clarified. In recent years, the importance of lifestyle, patient comorbidities, and prescribed medication has attracted more attention in the efficacy of cell therapy. As a nonsteroidal anti-inflammatory drug, aspirin is one of the most prevalent prescribed medications in the clinic for various disorders. Hence, aspirin treatment might affect the efficacy of stem cell therapy. In this regard, the current review focused on the impacts of aspirin on the viability, proliferation, differentiation, and immunomodulatory properties of stem cells in vitro as well as in experimental animal models.

Automated summary

This review examines the effects of aspirin on stem cell therapy, focusing on its impact on the viability, proliferation, differentiation, and immunomodulatory properties of cells in vitro and in animal models.