期刊
TETRAHEDRON LETTERS
卷 93, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2022.153690
关键词
Merosesquiterpenes; Marine sponge; Spongia pertusa Esper; Antifungal activity; Table 1
资金
- National Key Research and Development Program of China [2018YFC0310900]
- National Natural Science Foundation of China [22137006, 82073758]
- Shanghai Rising-Star Program [19QA1405300]
- Interdisciplinary fund of Renji Hospital [RJTJ-JX-004]
- Training Program for Excellent Young Innovators of Changsha [kq2106073]
- Open Project of National Major Science and Technology Infrastructure of Translational Medicine [TMSK-2021-206]
- Special Project for Marine Economic Development of Department of Natural Resources of Guangdong Province [GDNRC[2020]039, GDNRC [2021]48]
Three new merosesquiterpenoids were isolated from a marine sponge and characterized using NMR spectroscopy and HRESIMS. One of the compounds exhibited moderate antifungal activity against three human pathogens.
Three new merosesquiterpenoids, 24-methylsulfinyllancoquinone B (1), pelorol A (2), and epi-langconol A (3), along with eight known related analogues, were isolated from a marine sponge Spongia pertusa Esper. The compounds were completely characterized by NMR spectroscopy and HRESIMS. Compound 1 had a friedo-drimane sesquiterpenoid skeleton bearing a rare 3-(methylsulfinyl)propan-1-amine func-tionality, whereas 2 and 3 were members of the drimane-type sesquiterpenoid derivatives. Compounds 1, 4, 6, 7, and 8 exhibited moderate antifungal activity against three human pathogens, namely, Candida albicans, Trichophyton mentaqrophytes, and Trichophyton rubrum, with MIC50 values ranging from 12.5 to 50 lg/mL. (c) 2022 Elsevier Ltd. All rights reserved.
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