Sulfurated and iodinated metabolites from the cold-seep fungus Cladosporium cladosporioides 8-1

A novel sulfur-and peroxy-bridged twelve-membered macrolide, cladosporioidin A (1), and a new iodinated dimeric naphtho-c-pyrone, (aS)-6-iodofonsecinone A (2), were obtained from a marine cold-seep isolate (8-1) of Cladosporium cladosporioides. Their structures and relative/absolute configurations were unequivocally established by combination of various spectroscopic techniques, mainly including NMR, MS, and ECD. Compounds 1 and 2 were assayed to feature antimicroalgal and antibacterial activities. (c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

A novel sulfur-and peroxy-bridged twelve-membered macrolide, cladosporioidin A (1), and a new iodinated dimeric naphtho-c-pyrone, (aS)-6-iodofonsecinone A (2), were isolated from a marine cold-seep isolate of Cladosporium cladosporioides. Their structures and configurations were determined by various spectroscopic techniques, and both compounds showed antimicroalgal and antibacterial activities.