Microwave mediated synthesis of 2-aminooxazoles

A microwave mediated synthesis of 2-aminooxazoles at 150 degrees C was developed, providing products with a variety of functional groups. The reaction takes 5 min and provides product with a simple precipitation at moderate to good yields without the need for recrystallization or flash chromatography. (C) 2021 The Author(s). Published by Elsevier Ltd.

Automated summary

A method for the synthesis of 2-aminooxazoles at 150 degrees C using microwave irradiation was developed, providing products with various functional groups in a short reaction time and moderate to good yields, without the need for recrystallization or flash chromatography.